J Clin Oncol:田捷团队利用放射组学提高结直肠癌淋巴结转移预测准确性

2017-04-28 佚名 自动化研究所

中国科学院自动化研究所分子影像院重点实验室研究员田捷团队和广东省人民医院放射科合作,采用新兴的影像组学(Radiomics)方法在结直肠癌淋巴结转移预测研究方面取得新进展,相关研究成果近期在国际期刊《临床肿瘤学杂志》(Journal of Clinical Oncology)上在线发表。结直肠癌(Colorectal cancer)是人类最常见的消化道恶性肿瘤之一,其发病率和死亡率分别居所有癌症的

中国科学院自动化研究所分子影像院重点实验室研究员田捷团队和广东省人民医院放射科合作,采用新兴的影像组学(Radiomics)方法在结直肠癌淋巴结转移预测研究方面取得新进展,相关研究成果近期在国际期刊《临床肿瘤学杂志》(Journal of Clinical Oncology)上在线发表。

结直肠癌(Colorectal cancer)是人类最常见的消化道恶性肿瘤之一,其发病率和死亡率分别居所有癌症的第三位和第四位。结直肠癌深入盆腔,解剖关系复杂,手术不易彻底,术后复发率高。特别是如果结直肠癌患者合并淋巴结转移,将更难以治疗,必须在手术时对所有受侵犯的淋巴结进行彻底清扫,否则很有可能出现术后复发及转移。但是术前传统CT影像学难以判断淋巴结是否转移,也很难通过穿刺活检获得淋巴结转移信息;而术中对所有淋巴结盲目清扫又会带来很多不必要的副作用(如淋巴水肿等)。如何在术前进行较准确的淋巴结转移判断是当前结直肠癌临床中遇到的挑战性问题。

针对这一挑战性的问题,田捷团队和广东省人民医院放射科教授刘再毅、梁长虹团队合作,回顾分析了广东省人民医院2007-2011年间500余例进行结直肠癌手术的患者资料,利用新兴的影像组学方法,将影像特征、临床病理特征(血清标记物和临床指标)相结合,构建并验证了基于影像组学标签的结直肠癌淋巴结转移术前预测模型,用于对淋巴结转移的概率进行定量预测,和传统CT影像学评估相比,影像组学预测模型将术前淋巴结预测准确率提高了14.8%。利用研发的预测模型可以辅助临床医生进行结直肠癌的术前决策,具有重要的临床价值和应用前景。

影像组学(Radiomics)是利用数据挖掘等信息技术,从影像、病理、基因等海量数据中挖掘提取并量化肿瘤海量特征,解析影像与基因和临床信息(分型、疗效和预后等)关联的新方法。近年来影像组学已成为影像学领域最受关注的研究热点和前沿方向之一。

原始出处:

Yan-qi Huang, Chang-hong Liang, Lan He, et al.Development and Validation of a Radiomics Nomogram for Preoperative Prediction of Lymph Node Metastasis in Colorectal Cancer. Journal of Clinical Oncology 34, no. 18 (June 2016) 2157-2164.

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    2017-09-08 minlingfeng
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    2017-05-21 suibian2007bbb

    学习

    0

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    2017-05-20 suibian2007bbb

    放疗

    0

  4. 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    2017-05-05 lou.minghong

    学习了

    0

  6. 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    2017-04-30 ylzr123

    好文,值得点赞,更值得收藏!慢慢领会学习的。给点个赞!

    0

  7. 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createdName=suibian2007bbb, createdTime=Sun May 21 00:38:12 CST 2017, time=2017-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200330, encodeId=af3f2003308b, content=放疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4KDsF1g1gUHzGM0LHxX5B5uhEMln8y8iagso9N4XBTQVPmHrCNoT3o8bw80Ds53TpTgcPnKUIfkyw/0, createdBy=bc101976400, createdName=suibian2007bbb, createdTime=Sat May 20 08:42:33 CST 2017, time=2017-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1905898, encodeId=e6c2190589857, content=<a href='/topic/show?id=34953120e52' target=_blank style='color:#2F92EE;'>#准确性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31207, encryptionId=34953120e52, topicName=准确性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512a199, createdName=lilianxiang, createdTime=Sun Oct 15 21:40:00 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193888, encodeId=98bc193888a3, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Fri May 05 04:20:17 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192250, encodeId=940019225097, content=好文,值得点赞,更值得收藏!慢慢领会学习的。给点个赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Apr 30 19:42:57 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1292979, encodeId=cc3812929e935, content=<a href='/topic/show?id=df626600877' target=_blank style='color:#2F92EE;'>#淋巴结#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66008, encryptionId=df626600877, topicName=淋巴结)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Sun Apr 30 13:40:00 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1302503, encodeId=af4c1302503dc, content=<a href='/topic/show?id=7be06602886' target=_blank style='color:#2F92EE;'>#淋巴结转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66028, encryptionId=7be06602886, topicName=淋巴结转移)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Sun Apr 30 13:40:00 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452894, encodeId=355d14528948a, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Sun Apr 30 13:40:00 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191743, encodeId=ebdb191e431c, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sat Apr 29 09:15:16 CST 2017, time=2017-04-29, status=1, ipAttribution=)]
    2017-04-30 sodoo
  8. 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topicName=准确性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512a199, createdName=lilianxiang, createdTime=Sun Oct 15 21:40:00 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193888, encodeId=98bc193888a3, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Fri May 05 04:20:17 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192250, encodeId=940019225097, content=好文,值得点赞,更值得收藏!慢慢领会学习的。给点个赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], 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  9. 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  10. 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GetPortalCommentsPageByObjectIdResponse(id=191743, encodeId=ebdb191e431c, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sat Apr 29 09:15:16 CST 2017, time=2017-04-29, status=1, ipAttribution=)]
    2017-04-29 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

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