Clinical Gastroenterology H: 肝硬化患者体弱与肌肉减少症之间关联

2020-01-22 不详 MedSci原创

体力衰弱在肝硬化患者中普遍存在,据推测部分原因是肌肉减少症所致,但人们对肌肉减少症对衰弱的确切贡献知之甚少。因此,本项研究旨在探究二者的关系。

目标:
体力衰弱在肝硬化患者中普遍存在,据推测部分原因是肌肉减少症所致,但人们对肌肉减少症对衰弱的确切贡献知之甚少。因此,本项研究旨在探究二者的关系。

方法:
本项研究共纳入2011年至2014年的肝硬化患者,他们在3个月内进行了门诊脆弱性评估和腹部CT扫描。Logistic回归评估了体力虚弱(肝脏虚弱指数≥4.5)和肌肉减少症(女性的骨骼肌指数<39 cm2/m2和男性的骨骼肌指数<50 cm2/m2)之间的关联。

结果:
本项研究最终纳入211名参与者:33%是女性。中位(四分位间距)肝脏衰弱指数为3.7(3.3-4.2);19%虚弱。骨骼肌指数为49 cm2/m2(31–69); 36%患有肌肉减少症。在54名虚弱的参与者中,有48%患有肌肉减少症。在单变量logistic回归中,肌肉减少症与脆弱的几率增加1.86倍(95%置信区间[CI],1.02–3.38)。在对性别,病因,肝细胞癌,MELDNa,腹水,脑病和高血压进行调整后,肌肉减少症的体弱的几率增加了2.38倍(95%CI,1.17–4.85)。在按性别分层并调整了MELDNa之后,男性的肌肉减少症与体弱的几率显着相关(优势比为2.81、95%CI,1.19–6.67)。

讨论:
在肝硬化患者中,肌肉减少症与体弱的几率增加了近两倍。三分之二的衰弱男性表现出肌肉减少症。

原始出处:

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    2020-04-12 许安
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    2020-01-24 zll0628
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    2020-01-22 guging

    谢谢!最新的信息读起来就是收获大

    0

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