Am J Gastroenterology:回盲部吻合术类型对术后克罗恩病患者的长期功能状态,生活质量和保健利用有显着影响,与炎症复发无关

2018-04-07 MedSci MedSci原创

克罗恩氏病(CD)肠切除术后的吻合口重建可采用侧-侧吻合(STSA;抗蠕动方向)或端-端吻合术(ETEA)。本项研究的目的是确定这两种吻合技术对术后CD患者长期临床状态的影响。

目的与背景:

克罗恩氏病(CD)肠切除术后的吻合口重建可采用侧-侧吻合(STSA;抗蠕动方向)或端-端吻合术(ETEA)。本项研究的目的是确定这两种吻合技术对术后CD患者长期临床状态的影响。

方法:

为了评估吻合类型与术后2年生活质量之间的关系,研究人员对从2008年至2012年接受第一次或第二次回结肠肠切除术和再吻合术的CD患者进行前瞻性观察,并对数据进行了有效性研究( QoL),疾病临床或内镜复发,药物使用以及需要重复切除的比较。

结果:

对一百二十八名术后CD患者(60名STSA和68名ETEA)进行了评估。术后2年,STSA患者的急诊科就诊率(33.3%vs14.7%,P = 0.01),住院率(30%vs11.8%,P = 0.01)和腹部计算机断层扫描(50%vs13.2%; P <0.001)具有较低的QoL(平均短炎性肠病问卷47.9vs53.4; P = 0.007)。两组在30天手术并发症和2年疾病活动模式,CD用药需求,内镜复发以及需要新的手术治疗方面没有差异(P > 0.05)。

结论:

术后2年,与STSA相比,尽管疾病复发和CD治疗的模式类似,但ETEA的CD患者生活质量更好,医疗利用率更低。这些研究结果表明,作为一个完整的管(ETEA)的肠手术重建有助于改善CD患者的功能和临床状态。

原始出处:
MPH,Mahesh Gajendran. Et al. Ileocecal Anastomosis Type Significantly Influences Long-Term Functional Status, Quality of Life, and Healthcare Utilization in Postoperative Crohn's Disease Patients Independent of Inflammation Recurrence. Am J Gastroenterology. 2018.

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    2019-03-15 许安
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    2018-04-07 明月清辉

    谢谢分享.学习了

    0