JAHA:房颤与肺栓塞和缺血性卒中的病因特异性风险!

2018-01-29 xing.T MedSci原创

由此可见,房颤与PE和缺血性卒中的病因特异性风险增加有关。该研究结果推断房颤患者的PE风险没有通过缺血性卒中来介导。

房颤是缺血性卒中的一个已知的危险因素。新的证据也表明房颤与肺栓塞(PE)之间存在关联。因为在房颤患者中缺血性卒中可能潜在地介导所观察到的PE风险。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章。研究人员的目的是通过从普通人群中招募的一个大队列来评估房颤对PE和缺血性卒中病因特异性风险的影响。

研究人员观察了来自于Tromsø研究的3个调查(分别在1994年-1995年、2001年-2002年、2007年-2008年)29842名参与者,至2012年底。在随访期间记录了房颤、缺血性卒中和PE事件的发生率,并获取了基线时相关的潜在混杂因素信息。研究人员采用以房颤为时间变量的Cox回归模型计算了PE和缺血性卒中的特定原因风险比(HRs)和95%可信区间(CI)。

在2067名被诊断为房颤患者中,中位随访17.6年期间,296名为PE患者,1164名为缺血性卒中患者。PE(HR为10.88,95%CI为6.23-18.89)和缺血性卒中(HR为6.16,95%CI为4.47-8.48)的风险在房颤诊断的前6个月内显著增加,PE的粗略发病率为每1000人每年18.5人,缺血性卒中的粗略发病率为每1000人每年52.8人。在整个研究期间,PE(HR为1.72,95%CI为1.10-2.71)和缺血性卒中(HR为2.45,95%CI为2.05-2.92)的风险估计仍然升高。

由此可见,房颤与PE和缺血性卒中的病因特异性风险增加有关。该研究结果推断房颤患者的PE风险没有通过缺血性卒中来介导。

原始出处:

Erin M. Hald,et al. Atrial Fibrillation and Cause‐Specific Risks of Pulmonary Embolism and Ischemic Stroke.JAHA.2018. https://doi.org/10.1161/JAHA.117.006502

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    2018-02-17 天涯183

    非常好的文章.学习了

    0

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beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b4b12216028, createdName=120e71dcm28暂无昵称, createdTime=Tue Jan 30 09:51:42 CST 2018, time=2018-01-30, status=1, ipAttribution=)]
    2018-02-03 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

  8. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b4b12216028, createdName=120e71dcm28暂无昵称, createdTime=Tue Jan 30 09:51:42 CST 2018, time=2018-01-30, status=1, ipAttribution=)]
    2018-01-31 虈亣靌

    谢谢分享学习了

    0

  9. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Wed Jan 31 19:59:01 CST 2018, time=2018-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267708, encodeId=03ee126e7083c, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Jan 31 10:38:00 CST 2018, time=2018-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283485, encodeId=74be2834859c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b4b12216028, createdName=120e71dcm28暂无昵称, createdTime=Tue Jan 30 09:51:42 CST 2018, time=2018-01-30, status=1, ipAttribution=)]
    2018-01-31 zhaohui6731
  10. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b4b12216028, createdName=120e71dcm28暂无昵称, createdTime=Tue Jan 30 09:51:42 CST 2018, time=2018-01-30, status=1, ipAttribution=)]
    2018-01-30 120e71dcm28暂无昵称

    学习了

    0

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