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Lancet Neurol：辛伐他汀对1型神经纤维瘤病患儿无效

2013-10-21 MedSci MedSci原创

辛伐他汀1型神经纤维瘤
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荷兰一项研究表明，在1型神经纤维瘤病患儿中，为期12个月的辛伐他汀治疗未能改善认知缺陷和行为问题，因此不推荐辛伐他汀20—40 mg/d用于改善1型神经纤维瘤患儿的认知功能。论文于10月1日在线发表于《柳叶刀·神经病学》（lancet Neurol）。此项随机对照试验共纳入84例年龄为8～16岁的1型神经纤维瘤病患儿，并以1:1比率随机给予12个月的辛伐他汀（n=43）或安慰剂（n=41）治疗。主

荷兰一项研究表明，在1型神经纤维瘤病患儿中，为期12个月的辛伐他汀治疗未能改善认知缺陷和行为问题，因此不推荐辛伐他汀20—40 mg/d用于改善1型神经纤维瘤患儿的认知功能。论文于10月1日在线发表于《柳叶刀·神经病学》（lancet Neurol）。

此项随机对照试验共纳入84例年龄为8～16岁的1型神经纤维瘤病患儿，并以1:1比率随机给予12个月的辛伐他汀（n=43）或安慰剂（n=41）治疗。主要转归为总体智商、注意力问题和内化行为问题。对基线表现进行校正之后，对12个月时转归评分进行意向治疗分析。

结果显示，为期12个月辛伐他汀治疗对总体智商（P=0.33）、注意力问题（P=0.23）和内化行为问题（P=0.96）均无显著影响。辛伐他汀和安慰剂组分别有88%和95%的患儿报告不良事件，严重不良事件则分别为2和4例。

原文检索：

van der Vaart T, Plasschaert E, Rietman AB, Renard M, Oostenbrink R, Vogels A, de Wit MC, Descheemaeker MJ, Vergouwe Y, Catsman-Berrevoets CE, Legius E, Elgersma Y, Moll HA.Simvastatin for cognitive deficits and behavioural problems in patients with neurofibromatosis type 1 (NF1-SIMCODA): a randomised, placebo-controlled trial.Lancet Neurol. 2013 Nov;12(11):1076-83. doi: 10.1016/S1474-4422(13)70227-8.

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    2013-12-21 howi

    #Lancet#

    0

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    2014-05-08 yinhl1978

    #Neurol#

    0

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    2013-10-23 zhangmingxiang

    #辛伐他汀#

    0

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    2013-10-23 12498474m30暂无昵称

    #纤维瘤#

    0

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    2013-10-23 stfoxst

    #神经纤维#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1827631, encodeId=ed1f182e6319f, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sat Dec 21 11:25:00 CST 2013, time=2013-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999347, encodeId=581b199934e55, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu May 08 07:25:00 CST 2014, time=2014-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368078, encodeId=451313680e8e5, content=<a href='/topic/show?id=f2fd938442c' target=_blank style='color:#2F92EE;'>#辛伐他汀#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93844, encryptionId=f2fd938442c, topicName=辛伐他汀)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c6fc262, createdName=zhangmingxiang, createdTime=Wed Oct 23 05:25:00 CST 2013, time=2013-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1387690, encodeId=2f5e138e690f1, content=<a href='/topic/show?id=f210e72532e' target=_blank style='color:#2F92EE;'>#纤维瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77253, encryptionId=f210e72532e, topicName=纤维瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fc62500009, createdName=12498474m30暂无昵称, createdTime=Wed Oct 23 05:25:00 CST 2013, time=2013-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489741, encodeId=4f4a1489e41d7, content=<a href='/topic/show?id=5293e447259' target=_blank style='color:#2F92EE;'>#神经纤维#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74472, encryptionId=5293e447259, topicName=神经纤维)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53f28597470, createdName=stfoxst, createdTime=Wed Oct 23 05:25:00 CST 2013, time=2013-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510776, encodeId=d5011510e7607, content=<a href='/topic/show?id=9acc6e0f7' target=_blank style='color:#2F92EE;'>#1型神经纤维瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=670, encryptionId=9acc6e0f7, topicName=1型神经纤维瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0f10248147, createdName=paperyu, createdTime=Wed Oct 23 05:25:00 CST 2013, time=2013-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1590536, encodeId=cf40159053683, content=<a href='/topic/show?id=1a13e725459' target=_blank style='color:#2F92EE;'>#纤维瘤病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77254, encryptionId=1a13e725459, topicName=纤维瘤病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fa7717811566, createdName=lixiao3332, createdTime=Wed Oct 23 05:25:00 CST 2013, time=2013-10-23, status=1, ipAttribution=)]
    2013-10-23 paperyu

    #1型神经纤维瘤#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1827631, encodeId=ed1f182e6319f, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sat Dec 21 11:25:00 CST 2013, time=2013-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999347, encodeId=581b199934e55, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu May 08 07:25:00 CST 2014, time=2014-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368078, encodeId=451313680e8e5, content=<a href='/topic/show?id=f2fd938442c' target=_blank style='color:#2F92EE;'>#辛伐他汀#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93844, encryptionId=f2fd938442c, topicName=辛伐他汀)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c6fc262, createdName=zhangmingxiang, createdTime=Wed Oct 23 05:25:00 CST 2013, time=2013-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1387690, encodeId=2f5e138e690f1, content=<a href='/topic/show?id=f210e72532e' target=_blank style='color:#2F92EE;'>#纤维瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77253, encryptionId=f210e72532e, topicName=纤维瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fc62500009, createdName=12498474m30暂无昵称, createdTime=Wed Oct 23 05:25:00 CST 2013, time=2013-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489741, encodeId=4f4a1489e41d7, content=<a href='/topic/show?id=5293e447259' target=_blank style='color:#2F92EE;'>#神经纤维#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74472, encryptionId=5293e447259, topicName=神经纤维)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53f28597470, createdName=stfoxst, createdTime=Wed Oct 23 05:25:00 CST 2013, time=2013-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510776, encodeId=d5011510e7607, content=<a href='/topic/show?id=9acc6e0f7' target=_blank style='color:#2F92EE;'>#1型神经纤维瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=670, encryptionId=9acc6e0f7, topicName=1型神经纤维瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0f10248147, createdName=paperyu, createdTime=Wed Oct 23 05:25:00 CST 2013, time=2013-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1590536, encodeId=cf40159053683, content=<a href='/topic/show?id=1a13e725459' target=_blank style='color:#2F92EE;'>#纤维瘤病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77254, encryptionId=1a13e725459, topicName=纤维瘤病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fa7717811566, createdName=lixiao3332, createdTime=Wed Oct 23 05:25:00 CST 2013, time=2013-10-23, status=1, ipAttribution=)]
    2013-10-23 lixiao3332

    #纤维瘤病#

    0

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