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Osteoporos Int：抗骨质疏松药能否有效预防二次骨折？

2017-12-28 王淳 环球医学

抗骨质疏松药
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2017年12月，发表在《Osteoporos Int》上的一项综述，对抗骨质疏松药物预防二次脆性骨折的有效性进行了系统评价和meta分析

2017年12月，发表在《Osteoporos Int》上的一项综述，对抗骨质疏松药物预防二次脆性骨折的有效性进行了系统评价和meta分析

骨质疏松性骨折患者发生二次骨折的风险增加。但是缺乏一项严格评估个体化骨质疏松药预防二次骨折有效性的研究。本综述旨在分析抗骨质疏松药预防二次骨折的有效性。研究人员在MEDLINE、Embase.com和Cochrane中心注册数据库中检索了报道使用抗骨质疏松药[双膦酸盐、选择性的雌激素受体调节剂、甲状旁腺素（PTH）或降血钙素]时二次骨折发生率的随机对照试验。研究人员评估了风险比（RR）和预防二次骨折的需要治疗的数量（NNT）。26项研究符合研究人员的纳入标准。使用抗骨质疏松药后二次脊椎骨折RR（0.38-0.77）显着降低。双膦酸盐和PTH能显着降低二次非脊椎骨折的风险（RR 0.59和0.64）。PTH需要最少数量的患者接受治疗以预防二次脊椎骨折（NNT：56）。研究人员的研究证实在研究人员系统评价中纳入的抗骨质疏松药能有效预防二次脊椎骨折。双膦酸盐和PTH预防非脊椎骨折最有效。研究人员建议临床医生应该处方这些药物来预防二级脊椎/非脊椎骨折。

原始出处：

Saito T，et al. Effectiveness of anti-osteoporotic drugs to prevent secondary fragility fractures： systematic review and meta-analysis. Osteoporos Int. 2017 Dec；28(12)：3289-3300. doi： 10.1007/s00198-017-4175-0. Epub 2017 Aug 2.

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    2018-04-01 ms6127405442416114

    #抗骨质疏松#

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    2017-12-30 Eleven17

    #骨质#

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