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BMC Nephrol：终末期肾病患者内毒素血症或是其心血管疾病发生的重要因素

2017-07-23 MedSci MedSci原创

内毒素血症终末期肾病心血管疾病
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心血管疾病是终末期肾病患者死亡的主要原因。大多数终末期肾病患者存在全身炎症反应，并会增加心血管事件发生的风险。革兰氏阴性菌脂多糖引起的内毒素占肠道细菌总数的70%，导致炎症因子释放，并影响心血管健康。某些终末期肾病患者存在肠屏障障碍，可能导致胃肠道细菌迁移。本研究旨在探讨终末期肾病患者内毒素血症与急性冠脉综合征（ACS）之间的关系。研究人员收集了2013年11月1日至2014年10月31日就诊于台

心血管疾病是终末期肾病患者死亡的主要原因。大多数终末期肾病患者存在全身炎症反应，并会增加心血管事件发生的风险。革兰氏阴性菌脂多糖引起的内毒素占肠道细菌总数的70%，导致炎症因子释放，并影响心血管健康。某些终末期肾病患者存在肠屏障障碍，可能导致胃肠道细菌迁移。本研究旨在探讨终末期肾病患者内毒素血症与急性冠脉综合征（ACS）之间的关系。

研究人员收集了2013年11月1日至2014年10月31日就诊于台湾南部奇美医学中心急诊部的伴有（30名患者）或不伴有（30名患者）ACS的成人终末期肾病患者。收集所有研究对象的临床资料和实验室数据。测定患者的血清内毒素水平。使用实时的16S rDNA PCR检测患者血液中可能存在的细菌。

结果，伴有ACS的终末期肾病患者的内毒素水平（0.49 (±0.12) EU/mL）明显高于不伴有ACS的患者（0.1 ± 0.08）（p＜0.01）。然而，内毒素水平与肌钙蛋白I水平无相关性（r =−0.12）。尽管终末期肾病患者血清内毒素的水平较高，但是并未检测到细菌。

总之，该研究发现表明，伴有ACS的终末期肾病患者的内毒素水平明显高于不伴有ACS的患者。提示内毒素血症可能是终末期肾病患者心血管疾病发生的重要因素。

原始出处：
Chien-Chin Hsu, Tsui-Shan Wei, et al., Endotoxemia is associated with acute coronary syndrome in patients with end stage kidney disease. BMC Nephrol. 2017; 18: 235. Published online 2017 Jul 12. doi: 10.1186/s12882-017-0652-0.

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    2018-01-27 ms3025846204744509

    #BMC#

    0

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    2018-06-29 anminleiryan

    #终末期#

    0

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createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Jul 24 12:57:27 CST 2017, time=2017-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225550, encodeId=880222555074, content=学习了，涨姿势, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Jul 23 21:07:56 CST 2017, time=2017-07-23, status=1, ipAttribution=)]
    2017-09-06 gostraight

    #肾病患者#

    0

  4. 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topicName=终末期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f6429431807, createdName=anminleiryan, createdTime=Fri Jun 29 21:13:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2025817, encodeId=62a4202581e79, content=<a href='/topic/show?id=a91d82583bf' target=_blank style='color:#2F92EE;'>#肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82583, encryptionId=a91d82583bf, topicName=肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Wed Sep 06 06:13:00 CST 2017, time=2017-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1704188, encodeId=10591e041880b, content=<a href='/topic/show?id=172330400dd' target=_blank style='color:#2F92EE;'>#内毒素#</a>, beContent=null, objectType=article, channel=null, level=null, 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time=2017-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1572949, encodeId=2d2e15e2949f9, content=<a href='/topic/show?id=62fa3040356' target=_blank style='color:#2F92EE;'>#内毒素血症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30403, encryptionId=62fa3040356, topicName=内毒素血症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=417b15789705, createdName=rgjl, createdTime=Tue Jul 25 03:13:00 CST 2017, time=2017-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225803, encodeId=e5f322580393, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Jul 24 12:57:27 CST 2017, time=2017-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225550, encodeId=880222555074, content=学习了，涨姿势, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Jul 23 21:07:56 CST 2017, time=2017-07-23, status=1, ipAttribution=)]
    2017-10-24 heli0118

    #内毒素#

    0

  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Jul 24 12:57:27 CST 2017, time=2017-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225550, encodeId=880222555074, content=学习了，涨姿势, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Jul 23 21:07:56 CST 2017, time=2017-07-23, status=1, ipAttribution=)]
    2017-07-25 ylzr123

    好文，值得点赞！认真学习了，把经验应用于实践，为患者解除病痛。

    0

  6. 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time=2017-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1572949, encodeId=2d2e15e2949f9, content=<a href='/topic/show?id=62fa3040356' target=_blank style='color:#2F92EE;'>#内毒素血症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30403, encryptionId=62fa3040356, topicName=内毒素血症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=417b15789705, createdName=rgjl, createdTime=Tue Jul 25 03:13:00 CST 2017, time=2017-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225803, encodeId=e5f322580393, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Jul 24 12:57:27 CST 2017, time=2017-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225550, encodeId=880222555074, content=学习了，涨姿势, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Jul 23 21:07:56 CST 2017, time=2017-07-23, status=1, ipAttribution=)]
    2017-07-25 zengjiayao

    #终末期肾病#

    0

  7. 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topicName=终末期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f6429431807, createdName=anminleiryan, createdTime=Fri Jun 29 21:13:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2025817, encodeId=62a4202581e79, content=<a href='/topic/show?id=a91d82583bf' target=_blank style='color:#2F92EE;'>#肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82583, encryptionId=a91d82583bf, topicName=肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Wed Sep 06 06:13:00 CST 2017, time=2017-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1704188, encodeId=10591e041880b, content=<a href='/topic/show?id=172330400dd' target=_blank style='color:#2F92EE;'>#内毒素#</a>, beContent=null, objectType=article, channel=null, level=null, 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time=2017-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1572949, encodeId=2d2e15e2949f9, content=<a href='/topic/show?id=62fa3040356' target=_blank style='color:#2F92EE;'>#内毒素血症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30403, encryptionId=62fa3040356, topicName=内毒素血症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=417b15789705, createdName=rgjl, createdTime=Tue Jul 25 03:13:00 CST 2017, time=2017-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225803, encodeId=e5f322580393, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Jul 24 12:57:27 CST 2017, time=2017-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225550, encodeId=880222555074, content=学习了，涨姿势, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Jul 23 21:07:56 CST 2017, time=2017-07-23, status=1, ipAttribution=)]
    2017-07-25 andy2090

    #血管疾病#

    0

  8. 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time=2017-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1572949, encodeId=2d2e15e2949f9, content=<a href='/topic/show?id=62fa3040356' target=_blank style='color:#2F92EE;'>#内毒素血症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30403, encryptionId=62fa3040356, topicName=内毒素血症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=417b15789705, createdName=rgjl, createdTime=Tue Jul 25 03:13:00 CST 2017, time=2017-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225803, encodeId=e5f322580393, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Jul 24 12:57:27 CST 2017, time=2017-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225550, encodeId=880222555074, content=学习了，涨姿势, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Jul 23 21:07:56 CST 2017, time=2017-07-23, status=1, ipAttribution=)]
    2017-07-25 rgjl

    #内毒素血症#

    0

  9. 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createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Jul 24 12:57:27 CST 2017, time=2017-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225550, encodeId=880222555074, content=学习了，涨姿势, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Jul 23 21:07:56 CST 2017, time=2017-07-23, status=1, ipAttribution=)]
    2017-07-24 清风拂面

    谢谢分享，学习了

    0

  10. 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createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Jul 24 12:57:27 CST 2017, time=2017-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225550, encodeId=880222555074, content=学习了，涨姿势, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Jul 23 21:07:56 CST 2017, time=2017-07-23, status=1, ipAttribution=)]
    2017-07-23 1ddf0692m34(暂无匿称)

    学习了，涨姿势

    0

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