J Rheumatol:创建虚弱指数作为系统性红斑狼疮的新型健康指标

2019-08-28 xiangting MedSci原创

即使在相对年轻的SLE患者队列中,虚弱也很常见。SLICC-FI是识别预后不良SLE患者的有用工具,但在使用该指数前需要对其进行验证。

这项研究使用来自系统性狼疮国际合作诊所(SLICC)初始队列的数据构建虚弱指数(FI),以作为系统性红斑狼疮(SLE)患者不良预后的易损指标。

SLICC初始队列由最近诊断SLE患者组成,这些患者每年进行临床和实验室评估。对于该分析,基线访问被定义为获得构建FI足够信息的首次研究访问。按照标准程序,SLICC数据库中的变量被评估为潜在健康缺陷。然后使用选定的健康缺陷来生成SLICC-FI。使用FI值的确定切点评估基线数据集中虚弱的患病率。

1683SLE患者(占总队列的92.1%)符合基线数据集的入选标准,多数为女性(89%),平均年龄(SD35.7岁(13.4),基线时的平均病程(SD18.8个月(15.7)。在222个变量中,48个满足SLICC-FI的入选标准。平均值(SDSLICC-FI0.170.08),范围为00.51。在基线时,基于SLICC-FI>0.2127.1%(95CI 25.0-29.2)的患者被归类为虚弱。

SLICC初始队列构建了可用于SLE患者的FI。即使在相对年轻的SLE患者队列中,虚弱也很常见。SLICC-FI是识别预后不良SLE患者的有用工具,但在使用该指数前需要对其进行验证。

原始出处:

Alexandra Legge. Construction of a Frailty Index as a Novel Health Measure in Systemic Lupus. J Rheumatol. 15 August 2019.

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


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