拿什么拯救你,我的孩子(母孕期感染乙肝、梅毒、艾滋病全攻略)

2018-01-18 刘水桂 SIFIC感染官微

随着二胎政策的实施,哪怕没有老人照料孩子,哪怕每天累成狗,哪怕被大宝怨怼,也挡不住越来越多育龄女性迈入二胎大军,不为别的,只要想着小宝宝肉乎乎的小身子,软软糯糯的一声“妈妈”,瞬间融化。

随着二胎政策的实施,哪怕没有老人照料孩子,哪怕每天累成狗,哪怕被大宝怨怼,也挡不住越来越多育龄女性迈入二胎大军,不为别的,只要想着小宝宝肉乎乎的小身子,软软糯糯的一声“妈妈”,瞬间融化。

只是怀孕终归有风险,特别是有传染性疾病的妈妈,心里那份担忧总比旁人多了一份。那当怀孕遇上乙肝、梅毒、艾滋病时,该如何去抉择呢?

怀孕期间会得传染病吗?

会的。记住以下要点:

怀孕的妇女可能会感染与没有怀孕的妇女相同的传染病。

妊娠不能为妇女或其婴儿提供额外的保护。

许多传染病是“沉默的”,或没有症状,所以你可能不知道你是否感染

在怀孕期间,你应该接受有关传染病检测。

如果证实有感染,后果可能会更严重,甚至危及生命。

如果你在怀孕期间被诊断为性传播疾病,你的性伴侣也应进行相应的检测和治疗。

传染病对孕妇和婴儿有何影响?

乙肝是由乙型肝炎病毒(HBV)引起。母亲可能在怀孕期间将感染传染给她的宝宝,有先兆流产史的母亲宝宝感染的几率更大。母亲将HBV传染给她的宝宝的风险随着受感染时间的不同而不同,在分娩时,胎儿受到感染的风险最大。

梅毒是性传播疾病,怀孕期间可能由母亲传染给婴儿,导致婴儿先天性梅毒。梅毒孕妇容易导致早产和死胎。先天性梅毒在胎儿期可表现为肝脏肿大,胎盘增厚,胎儿水肿,宫内生长迟缓。出生后先天性梅毒多表现为早产儿,低体重儿或小于胎龄儿。晚期先天性梅毒甚至会出现智力发育迟缓。

人类免疫缺陷病毒(HIV)是导致获得性免疫缺陷综合征(艾滋病)的病毒。艾滋病毒会破坏对帮助身体抗击疾病至关重要的特定血细胞。艾滋病病毒通过母婴传播最常见的时机是在怀孕、分娩或哺乳期间。然而,当艾滋病病毒在怀孕之前或怀孕期间被诊断并采取适当的措施时,母婴传播的风险可以降低到2%以下。

怀孕期间可以接受传染病治疗吗?

1.乙肝

医务人员应当详细了解其肝炎病史及治疗情况,密切监测肝脏功能,给予科学的营养支持和指导。乙肝病毒表面抗原阳性孕妇在妊娠中后期根据HBV DNA载量大于2×10^6IU/ml(10^7拷贝/ml)给予替比夫定600mg/d口服或拉米夫定100mg/d口服,至分娩后4周停止抗病毒治疗。乙肝表面抗原阳性孕产妇所生新生儿,在出生后24小时内注射乙肝免疫球蛋白(100国际单位)。按照国家免疫规划要求,完成24小时内及1月龄和6月龄儿童的三次乙肝疫苗接种。乙肝疫苗与乙肝免疫球蛋白的接种部位不能是同一部位。

2.梅毒

对于孕早期发现的梅毒感染孕妇,应当在孕早期与孕晚期各提供1个疗程的抗梅毒治疗;对于孕中、晚期发现的感染孕妇,应当立刻给予2个疗程的抗梅毒治疗,2个治疗疗程之间需间隔4周以上(最少间隔2周),第2个疗程应当在孕晚期进行。对临产时发现的梅毒感染产妇也应当立即给予治疗。在孕妇治疗梅毒期间应当进行随访,若发现其再次感染或复发,应当立即再开始一个疗程的梅毒治疗。所有梅毒感染孕妇的性伴侣应进行梅毒血清学检测及梅毒治疗。 梅毒治疗后第一年内应每3个月复查血清一次,以后每6个月一次,共3年。

表1   梅毒治疗方案及替代方案



3.艾滋病

艾滋病孕妇不是实施剖宫产的指征。艾滋病孕妇分娩后,无论母乳喂养还是人工喂养,均无需停抗病毒药物。 婴儿出生后尽早(6-12小时内)开始服用抗病毒药物,对艾滋病感染孕产妇所生儿童提倡人工喂养,避免母乳喂养,杜绝混合喂养。对于因不具备人工喂养条件而选择母乳喂养的感染产妇及其家人,要做好充分的咨询,指导其坚持正确的纯母乳喂养,喂养时间最好不超过6个月,同时积极创造条件,尽早改为人工喂养。

表2    艾滋病的治疗方案



表3    常用抗病毒药物剂量及使用方法



孕期感染传染病并不可怕,积极配合医生的治疗,按时服药,同样可以生一个聪明漂亮健康的宝宝。

原始出处:

[1]预防艾滋病、梅毒和乙肝母婴传播工作实施方案(2015年).

[2]谢幸, 苟文丽. 妇产科学[M]. 第8版. 北京:人民卫生出版社,2013.102-108.

[3]牛兆仪,王芳,靳晴等.乙型肝炎病毒母婴垂直传播与乙肝抗原及乙肝DNA载量的关系研究[J],中外医疗,2014,27:105-106.

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time=2018-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279996, encodeId=82262e999640, content=了解了解.学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Fri Jan 19 09:05:39 CST 2018, time=2018-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279987, encodeId=4ed32e99878c, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Jan 19 09:02:23 CST 2018, time=2018-01-19, status=1, 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createdTime=Fri Jan 19 08:07:14 CST 2018, time=2018-01-19, status=1, ipAttribution=)]
    2018-10-25 Sunny8806

    内容很好 但是药品需要更新。乙肝母婴阻断已经专家共识使用替诺福韦 原研的韦瑞德目前用于母婴阻断是欧肝美肝指南唯一推荐 希望作者更新内容 谢谢

    0

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createdTime=Fri Jan 19 08:07:14 CST 2018, time=2018-01-19, status=1, ipAttribution=)]
    2018-01-22 haige

    学习了!谢啦!

    0

  3. 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  4. 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    2018-01-19 xxj12345678

    乙肝治愈药什么时候能上市呢?

    0

  5. 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    2018-01-19 天涯183

    非常好的文章.学习了

    0

  6. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279977, encodeId=dab22e99772a, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Fri Jan 19 08:51:12 CST 2018, time=2018-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279966, encodeId=2ec52e99668b, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Fri Jan 19 08:07:14 CST 2018, time=2018-01-19, status=1, ipAttribution=)]
    2018-01-19 15121100f4m

    谢谢.收藏了

    0

  7. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279977, encodeId=dab22e99772a, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Fri Jan 19 08:51:12 CST 2018, time=2018-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279966, encodeId=2ec52e99668b, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Fri Jan 19 08:07:14 CST 2018, time=2018-01-19, status=1, ipAttribution=)]
    2018-01-19 1dd8c52fm63(暂无匿称)

    了解了解.学习学习

    0

  8. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279977, encodeId=dab22e99772a, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Fri Jan 19 08:51:12 CST 2018, time=2018-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279966, encodeId=2ec52e99668b, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Fri Jan 19 08:07:14 CST 2018, time=2018-01-19, status=1, ipAttribution=)]
    2018-01-19 明月清辉

    谢谢分享.学习了

    0

  9. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279977, encodeId=dab22e99772a, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Fri Jan 19 08:51:12 CST 2018, time=2018-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279966, encodeId=2ec52e99668b, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Fri Jan 19 08:07:14 CST 2018, time=2018-01-19, status=1, ipAttribution=)]
    2018-01-19 龙胆草

    学习谢谢分享

    0

  10. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280921, encodeId=d6ec2809217d, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Mon Jan 22 09:23:21 CST 2018, time=2018-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280097, encodeId=199e28009e90, content=乙肝治愈药什么时候能上市呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIHqM5e4FkG3BORCSicB8ew4OzNZ92GtUwkbRiaslmkq9iaHiaE3NyHN0iaXMpiaRRS5RwptblyHOSt57Hg/132, createdBy=5a2e2252355, createdName=xxj12345678, createdTime=Fri Jan 19 17:25:04 CST 2018, time=2018-01-19, status=1, ipAttribution=), 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createdTime=Fri Jan 19 08:07:14 CST 2018, time=2018-01-19, status=1, ipAttribution=)]
    2018-01-19 Y—xianghai

    学习了新知识

    0

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