Maturitas:缺乏维生素D的绝经女性或易患代谢综合征

2018-04-02 xujing 中国循环杂志

巴西圣保罗大学的学者研究发现,体内维生素D水平低的绝经女性患代谢综合征的风险显著高于不缺乏维生素D的女性。


巴西圣保罗大学的学者研究发现,体内维生素D水平低的绝经女性患代谢综合征的风险显著高于不缺乏维生素D的女性。
 
维生素D缺乏症被定义为血清25-羟维生素D水平低于20 ng/ml,而20~29 ng/ml为不足,≥30 ng/ml被认为是充足。
 
代谢综合征诊断至少需满足5个标准中的3个:腰围>88cm,甘油三酯≥150 mg/dl,HDL水平<50 mg/dl,血压≥130/85 mm Hg,血糖≥100 mg/dl。
 
该研究中,超过一半(57.8%)的维生素D水平<30 ng/ml的女性有代谢综合征,而维生素D水平≥30 ng/ml的女性中有39.8%患有代谢综合征。
 
而且,维生素D<30 ng/ml与较高的总胆固醇、甘油三酯和胰岛素水平有关。
 
校正了年龄、绝经时间、体重指数、吸烟和体力活动水平后,维生素D缺乏的女性患代谢综合征的几率几乎是那些不缺乏维生素D女性的两倍。
 
缺乏维生素D的女性发生高甘油三酯的几率升高55%,低HDL的几率升高60%。维生素D浓度的降低与代谢综合征标准的增加有关。
 
对于病理生理机制,作者认为,维生素D影响胰岛素分泌和敏感性,这在代谢综合征中起着重要作用。
 
研究人员还注意到糖尿病患者和维生素D水平低的人群之间存在着共同的风险因素,如年龄大、少数民族/种族、肥胖和不运动。
 
研究者指出,户外活动减少和老年人皮肤合成维生素D的能力下降可能是导致绝经后女性中维生素D缺乏多见的主要原因。
 
该研究纳入463名绝经女性,45~75岁,未补充维生素D,无心血管疾病。
 
原始出处:

Jelena Milic et al.Menopause, ageing, and alcohol use disorders in women.Maturitas. 2018, 107: 97-102. .DOI: https://doi.org/10.1016/j.maturitas.2018.03.006

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