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Infect Dis： 在巴西亚马逊地区，对环子孢子蛋白进行血清价检测以评估恶性疟原虫、间日疟原虫和三日疟原虫的暴露风险

2018-04-25 MedSci MedSci原创

暴露风险
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<p class="MsoNormalCxSpFirst" style="margin-bottom:0cm;margin-bottom:.0001pt; mso-add-space:auto;text-align:justify;text-justify:inter-ideograph;line-height: normal;layout-grid-mode:char;mso-layout-

巴西的疟疾发病率大幅下降，且该国正在逐步推进实现消除疟疾的目标。然而，为了最终消除疟疾，控制项目需要有效的工具来监测疟疾的暴露和传播。在本研究中，我们的目的是评估环子孢子蛋白(CSP)的血清反应是否能够作为在巴西亚马逊地区监测疟原虫种类的暴露，或评估其负担和分布的良好工具。

研究在朗多尼亚州波尔图的农村地区进行横断面调查。用显微镜和聚合酶链反应检测原虫感染。用酶联免疫吸附法检测了间日疟原虫、恶性疟原虫和三日疟(PvCS、PfCS、PmCS)等环子孢子蛋白的抗体。利用荧光光谱技术对人类白细胞抗原(HLA)-DRB1和DQB1基因进行分类。

针对间日疟原虫CSP多肽的免疫球蛋白G(62%)的流行率高于恶性疟原虫(49%)和三日疟(46%)。大多数被研究的个体至少有三种肽中的一种抗体(72%)，34%的个体具有有三种肽的抗体，28%为阴性。虽然大多数人在调查时没有感染，但74.3%的原虫阴性个体至少有一种CSPs抗体。更为重要的是，在携带单倍型DRB1*04~DQB1*03的个体中，对PfCS应答的频率明显更高，而对DRB1*16~DQB1*03单倍型，对PvCS和PfCS应答较高。相比之下，HLA-DRB1*01和HLA-DQB1*05等位基因组与缺乏间日疟和恶性疟CSP重复的抗体相关，单倍型DRB1*01~DQB1*05与无应答相关，包括对三日疟。

我们的结果表明,在地传播地区,在一个横断面研究获得的对间日疟原虫CSP重复,恶性疟原虫和三日疟原虫自然获得抗体反应，可能不能作为对最近疟疾暴露的有价值的监测方法。特别是在间日疟流行率很高地区。此外，需要对在抗体反应中起着重要的作用的HLA第II类分子开展进一步样本量更大的研究。在使用血清学监测来监测遗传多样性人群中疟疾暴露的情况时，应该考虑HLA分析。

原始出处：

Virginia Araujo Pereira, Juan Camilo Sánchez-Arcila,Evaluating seroprevalence to circumsporozoite protein to estimate exposure to P. falciparum, P. vivax, and P. malariae in the Brazilian Amazon.

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    2018-11-15 cmj8wellington

    #Dis#

    0

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    2018-04-26 ay2000fy

    #间日疟#

    0

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    2019-03-22 drwjr

    #亚马逊#

    0

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    2018-05-06 wxl882001

    学习一下

    0

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    2018-04-27 12498484m46(暂无昵称)

    #疟原虫#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2012657, encodeId=2b68201265ea2, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Thu Nov 15 16:23:00 CST 2018, time=2018-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1988133, encodeId=fe7a198813329, content=<a href='/topic/show?id=1b9f9e2582d' target=_blank style='color:#2F92EE;'>#间日疟#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97258, encryptionId=1b9f9e2582d, topicName=间日疟)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f34c147, createdName=ay2000fy, createdTime=Thu Apr 26 21:23:00 CST 2018, time=2018-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1940496, encodeId=72b8194049630, content=<a href='/topic/show?id=41a12431862' target=_blank style='color:#2F92EE;'>#亚马逊#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24318, encryptionId=41a12431862, topicName=亚马逊)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Fri Mar 22 17:23:00 CST 2019, time=2019-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=312600, encodeId=22ba312600cc, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sun May 06 17:15:35 CST 2018, time=2018-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1387856, encodeId=0e51138e856b1, content=<a href='/topic/show?id=25ffe04313d' target=_blank style='color:#2F92EE;'>#疟原虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70431, encryptionId=25ffe04313d, topicName=疟原虫)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e622500011, createdName=12498484m46(暂无昵称), createdTime=Fri Apr 27 11:23:00 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578831, encodeId=3f5115e8831de, content=<a href='/topic/show?id=9b395292257' target=_blank style='color:#2F92EE;'>#恶性疟原虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52922, encryptionId=9b395292257, topicName=恶性疟原虫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b5f16444736, createdName=ms6832696159214430, createdTime=Fri Apr 27 11:23:00 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580856, encodeId=0362158085696, content=<a href='/topic/show?id=cc274831170' target=_blank style='color:#2F92EE;'>#巴西#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48311, encryptionId=cc274831170, topicName=巴西)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=81dd16663079, createdName=ms9833124466084992, createdTime=Fri Apr 27 11:23:00 CST 2018, time=2018-04-27, status=1, ipAttribution=)]
    2018-04-27 ms6832696159214430

    #恶性疟原虫#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2012657, encodeId=2b68201265ea2, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Thu Nov 15 16:23:00 CST 2018, time=2018-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1988133, encodeId=fe7a198813329, content=<a href='/topic/show?id=1b9f9e2582d' target=_blank style='color:#2F92EE;'>#间日疟#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97258, encryptionId=1b9f9e2582d, topicName=间日疟)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f34c147, createdName=ay2000fy, createdTime=Thu Apr 26 21:23:00 CST 2018, time=2018-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1940496, encodeId=72b8194049630, content=<a href='/topic/show?id=41a12431862' target=_blank style='color:#2F92EE;'>#亚马逊#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24318, encryptionId=41a12431862, topicName=亚马逊)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Fri Mar 22 17:23:00 CST 2019, time=2019-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=312600, encodeId=22ba312600cc, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sun May 06 17:15:35 CST 2018, time=2018-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1387856, encodeId=0e51138e856b1, content=<a href='/topic/show?id=25ffe04313d' target=_blank style='color:#2F92EE;'>#疟原虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70431, encryptionId=25ffe04313d, topicName=疟原虫)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e622500011, createdName=12498484m46(暂无昵称), createdTime=Fri Apr 27 11:23:00 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578831, encodeId=3f5115e8831de, content=<a href='/topic/show?id=9b395292257' target=_blank style='color:#2F92EE;'>#恶性疟原虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52922, encryptionId=9b395292257, topicName=恶性疟原虫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b5f16444736, createdName=ms6832696159214430, createdTime=Fri Apr 27 11:23:00 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580856, encodeId=0362158085696, content=<a href='/topic/show?id=cc274831170' target=_blank style='color:#2F92EE;'>#巴西#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48311, encryptionId=cc274831170, topicName=巴西)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=81dd16663079, createdName=ms9833124466084992, createdTime=Fri Apr 27 11:23:00 CST 2018, time=2018-04-27, status=1, ipAttribution=)]
    2018-04-27 ms9833124466084992

    #巴西#

    0