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CTS全国呼吸病学学术会议：杨媛华：CTEPH靶向治疗-药物选择与疗效分析

2017-09-25 张竹 呼吸界

慢性阻塞性肺动脉高压靶向药物随机对照试验
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在中华医学会呼吸病学年会-2017第十八次全国呼吸病学学术会议上，首都医科大学附属北京朝阳医院杨媛华教授总结了目前已知的CTEPH（慢性阻塞性肺动脉高压）靶向药物RCT研究，对CTEPH患者靶向治疗进行了完整的回顾和总结。

在中华医学会呼吸病学年会-2017第十八次全国呼吸病学学术会议上，首都医科大学附属北京朝阳医院杨媛华教授总结了目前已知的CTEPH（慢性阻塞性肺动脉高压）靶向药物RCT研究，对CTEPH患者靶向治疗进行了完整的回顾和总结。

杨媛华教授介绍，目前针对肺动脉高压的靶向药物主要为内皮素受体拮抗剂、磷酸二酯酶-5抑制剂、前列环素类似物、可溶性鸟苷酸环化酶受体激动剂等。其中针对CTEPH的4项RCT研究分别为波生坦（BENEFIT）、西地那非、Riociguat（CHEST-1、2）、马西替坦（MERIT-1）。

杨媛华教授对4项研究进行了详细分析对比。结果提示，波生坦及西地那非较安慰剂相比，主要终点事件：6分钟步行距离均无明显改善。而Riociguat无论短期结果还是长期随访研究均提示无论是主要终点事件（6分钟步行距离）还是次要终点事件（血流动力学及生物标志物）较安慰剂相比，均有显着性差异。马西替坦研究目前还未正式发表，但前期结果已提示该药物可显着改善CTEPH患者6分钟步行距离。

杨媛华教授总结，对于多学科讨论认为不能手术的CTEPH患者以及PEA术后残存PH患者，应考虑靶向药物治疗。目前仅有2项RCT研究显示，对于不能手术的CTEPH患者，药物治疗能改善患者的血流动力学和运动能力，但仍需进行RCT研究进一步证实联合治疗（初始联合或序贯联合）对CTEPH患者的有效性。未来前路漫漫。

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    2018-01-09 sjzlzc007

    #药物选择#

    0

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    2018-05-10 rebeccajiejie

    #疗效分析#

    0

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    2018-06-22 axin009

    #学术会议#

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    2018-08-06 ms9833124466084992

    #呼吸病#

    0

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    2018-06-26 ms306040998833292

    #呼吸病学#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2010715, encodeId=70142010e152b, content=<a href='/topic/show?id=e41b8e8837b' target=_blank style='color:#2F92EE;'>#药物选择#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87883, encryptionId=e41b8e8837b, topicName=药物选择)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=917c196, createdName=sjzlzc007, createdTime=Tue Jan 09 21:46:00 CST 2018, time=2018-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1647180, encodeId=1b5f164e1800e, content=<a href='/topic/show?id=e9bae04003f' target=_blank style='color:#2F92EE;'>#疗效分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70400, encryptionId=e9bae04003f, topicName=疗效分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=219323401160, createdName=rebeccajiejie, createdTime=Thu May 10 07:46:00 CST 2018, time=2018-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1904692, encodeId=5263190469208, content=<a href='/topic/show?id=85fa455346c' target=_blank style='color:#2F92EE;'>#学术会议#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45534, encryptionId=85fa455346c, topicName=学术会议)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ad8182, createdName=axin009, createdTime=Fri Jun 22 05:46:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1663427, encodeId=e05b166342e9b, content=<a href='/topic/show?id=2653396e53b' target=_blank style='color:#2F92EE;'>#呼吸病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39675, encryptionId=2653396e53b, topicName=呼吸病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ed5525610796, createdName=ms9833124466084992, createdTime=Mon Aug 06 07:46:00 CST 2018, time=2018-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1688046, encodeId=4f1716880463b, content=<a href='/topic/show?id=577a396e60f' target=_blank style='color:#2F92EE;'>#呼吸病学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39676, encryptionId=577a396e60f, topicName=呼吸病学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99a28444895, createdName=ms306040998833292, createdTime=Tue Jun 26 22:46:00 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461939, encodeId=54c51461939c2, content=<a href='/topic/show?id=10bf5438bc' target=_blank style='color:#2F92EE;'>#CTS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5438, encryptionId=10bf5438bc, topicName=CTS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Wed Sep 27 01:46:00 CST 2017, time=2017-09-27, status=1, ipAttribution=)]
    2017-09-27 docwu2019

    #CTS#

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