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Nanoscale：氧化石墨烯-银纳米复合材料对生物膜的调节作用

2018-11-01 MedSci MedSci原创

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有害和有益生物膜是在医学感染、环境修复和工业处理中发挥重要作用。然而，控制有害生物膜的生长以及利用有益的生物膜仍然具有挑战性。在这里，我们研究了抗菌氧化石墨烯-银纳米粒子（GO-AgNPs）复合物对铜绿假单胞菌生物膜形成的影响。 结果显示，GO-AgNPs以剂量依赖性方式阻止生物膜形成，阈值为15μgmL-1。有趣的是，细菌生物量显著降低，但在用适当浓度的GO-AgNP处理的成熟生物膜中细胞

有害和有益生物膜是在医学感染、环境修复和工业处理中发挥重要作用。然而，控制有害生物膜的生长以及利用有益的生物膜仍然具有挑战性。在这里，我们研究了抗菌氧化石墨烯-银纳米粒子（GO-AgNPs）复合物对铜绿假单胞菌生物膜形成的影响。

结果显示，GO-AgNPs以剂量依赖性方式阻止生物膜形成，阈值为15μgmL-1。有趣的是，细菌生物量显著降低，但在用适当浓度的GO-AgNP处理的成熟生物膜中细胞外聚合物（EPS）产生显著增加，表明GO-AgNP有效地调节生物膜的发育和结构。此外，我们确定GO-AgNPs通过物理损伤和氧化应激引起细菌死亡，显示GO和AgNPs的协同作用。

综上所述，这些发现促进了石墨烯基纳米复合材料作为更绿色的抗生素应用。

原始出处：

Liu S, Cao S, et al., Graphene oxide-silver nanocomposites modulate biofilm formation and extracellular polymeric substance (EPS) production. Nanoscale. 2018 Oct 16. doi: 10.1039/c8nr04064h.

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    2019-08-03 yangjxjc

    #石墨烯#

    0

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    2019-07-29 ms7899726347904398

    #化石#

    0

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    2019-10-17 zhangying8788

    #scale#

    0

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    2019-06-13 ms4964546379600229

    #复合材料#

    0

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    2019-01-07 cooco

    #纳米复合材料#

    0