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Invest Ophthalmol Vis Sci：视网膜色素变性患者中视网膜结构与焦点黄斑视网膜电图之间的关系

2017-10-15 cuiguizhong MedSci原创

视网膜色素变性视网膜结构焦点黄斑光学相干断层扫描
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日本名古屋大学医学研究院眼科系的Kominami T近日在Invest Ophthalmol Vis Sci杂志上发表了他们近期的一项工作。他们早期的研究表明，光感受器的完整椭圆形区域（EZ）的宽度与焦点性黄斑ERG（FMERG）的幅度存在相关性，但是弱相关。他们这次发表文章的研究目的是通过谱域光学相干断层扫描（SD-OCT）技术，研究光感受器的微观结构，研究SD-OCT与视网膜色素变性（RP）眼

日本名古屋大学医学研究院眼科系的Kominami T近日在Invest Ophthalmol Vis Sci杂志上发表了他们近期的一项工作。他们早期的研究表明，光感受器的完整椭圆形区域（EZ）的宽度与焦点性黄斑ERG（FMERG）的幅度存在相关性，但是弱相关。他们这次发表文章的研究目的是通过谱域光学相干断层扫描（SD-OCT）技术，研究光感受器的微观结构，研究SD-OCT与视网膜色素变性（RP）眼睛中的FMERG参数的关系。他们采用回顾性观察研究的方法，回顾分析了65例视网膜色素变性患者的病历资料。通过15种梯度的刺激点来引起FMERGs。在视网膜色素上皮的中央凹15度内的SD-OCT图像中，评估椭圆形区域（EZ）和被椭圆形区域（EZ）包围的外部段区域（OS）的宽度。使用Spearman相关性检验和多次逐步回归分析等方法进行统计学分析。结果他们发现，FMERG的幅度和EZ宽度之间存在很强的相关性（a波幅度r = 0.68； b波振幅r = 0.64），在FMERG的幅度和OS区域面积之间也存在这强烈的相关性（a波幅度r = 0.69； b波幅度r = 0.67）。然而，一些患者的EZ宽

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    2018-03-14 xiangyuzhou971

    #EST#

    0

  2. 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    2018-09-28 12498ca5m94暂无昵称

    #视网膜色素变性#

    0

  3. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253267, encodeId=20a625326e58, content=精彩.精彩.谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Mon Oct 16 05:44:59 CST 2017, time=2017-10-16, status=1, ipAttribution=)]
    2018-09-30 sunylz

    #色素#

    0

  4. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253267, encodeId=20a625326e58, content=精彩.精彩.谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Mon Oct 16 05:44:59 CST 2017, time=2017-10-16, status=1, ipAttribution=)]
    2017-10-17 zutt

    #视网膜#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2050865, encodeId=0d722050865ea, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Wed Mar 14 08:28:00 CST 2018, time=2018-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1740402, encodeId=72351e4040281, content=<a href='/topic/show?id=2d9990811c0' target=_blank style='color:#2F92EE;'>#视网膜色素变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90811, encryptionId=2d9990811c0, topicName=视网膜色素变性)], attachment=null, authenticateStatus=null, createdAvatar=null, 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content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4PNicOvbHfgIficrsEKztlD5yv1UnCFhnFmFU9yv1RHLflMRibWrppbsiccfMB8tT9HCkAr3zL2zVml/0, createdBy=89da1604922, createdName=䖝二, createdTime=Mon Oct 16 23:27:41 CST 2017, time=2017-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253285, encodeId=65a5253285cd, content=谢谢分享. , beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Mon Oct 16 06:26:25 CST 2017, time=2017-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253267, encodeId=20a625326e58, content=精彩.精彩.谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Mon Oct 16 05:44:59 CST 2017, time=2017-10-16, status=1, ipAttribution=)]
    2017-10-17 huangdf

    #变性#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2050865, encodeId=0d722050865ea, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Wed Mar 14 08:28:00 CST 2018, time=2018-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1740402, encodeId=72351e4040281, content=<a href='/topic/show?id=2d9990811c0' target=_blank style='color:#2F92EE;'>#视网膜色素变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90811, encryptionId=2d9990811c0, topicName=视网膜色素变性)], attachment=null, authenticateStatus=null, createdAvatar=null, 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content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4PNicOvbHfgIficrsEKztlD5yv1UnCFhnFmFU9yv1RHLflMRibWrppbsiccfMB8tT9HCkAr3zL2zVml/0, createdBy=89da1604922, createdName=䖝二, createdTime=Mon Oct 16 23:27:41 CST 2017, time=2017-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253285, encodeId=65a5253285cd, content=谢谢分享. , beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Mon Oct 16 06:26:25 CST 2017, time=2017-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253267, encodeId=20a625326e58, content=精彩.精彩.谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Mon Oct 16 05:44:59 CST 2017, time=2017-10-16, status=1, ipAttribution=)]
    2017-10-17 智慧医人

    #黄斑#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2050865, encodeId=0d722050865ea, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Wed Mar 14 08:28:00 CST 2018, time=2018-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1740402, encodeId=72351e4040281, content=<a href='/topic/show?id=2d9990811c0' target=_blank style='color:#2F92EE;'>#视网膜色素变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90811, encryptionId=2d9990811c0, topicName=视网膜色素变性)], attachment=null, authenticateStatus=null, createdAvatar=null, 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253267, encodeId=20a625326e58, content=精彩.精彩.谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Mon Oct 16 05:44:59 CST 2017, time=2017-10-16, status=1, ipAttribution=)]
    2017-10-17 1249842em13(暂无昵称)

    #THA#

    0

  8. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253267, encodeId=20a625326e58, content=精彩.精彩.谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Mon Oct 16 05:44:59 CST 2017, time=2017-10-16, status=1, ipAttribution=)]
    2017-10-16 䖝二

    有意思

    0

  9. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253267, encodeId=20a625326e58, content=精彩.精彩.谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Mon Oct 16 05:44:59 CST 2017, time=2017-10-16, status=1, ipAttribution=)]
    2017-10-16 doctorJiangchao

    谢谢分享.

    0

  10. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253267, encodeId=20a625326e58, content=精彩.精彩.谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Mon Oct 16 05:44:59 CST 2017, time=2017-10-16, status=1, ipAttribution=)]
    2017-10-16 yjs木玉

    精彩.精彩.谢谢了

    0

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ω-3减缓视网膜色素变性进展

一篇发表在JAMA/Archives期刊之一Archives of Ophthalmology上的报道，揭示患视网膜色素变性成年人服用VitA补充剂4至6年后，距离和视网膜视力年下降率缓慢，因服用富ω- 3脂肪酸的饮食。 视网膜色素变性是一种视网膜受损伤的眼疾。全世界大约2百万人（约1/4000）受这种典型的引起夜盲的疾病影响。症状通常首次出在儿童时期，但是诸如视野变小、管视和失明一样的严重

JAMA Ophthalmol：CNGB1相关的常染色体隐性遗传性视网膜色素变性的临床特征

视网膜色素变性（RP）的表型与CNGB1变异有关的研究数据极为有限，而这些研究数据有利于了解RP患者的预后信息和治疗窗。该研究描述了一些可能存在CNGB1病理性变异的RP患者的分子基因改变和临床症状表现。