Clin Gastroenterol H:饮料摄入与胃食道反流症状发生率之间的关联

2019-11-30 xing.T MedSci原创

由此可见,这项前瞻性护士健康研究II数据分析表明咖啡、茶或苏打水的摄入与GER症状风险增加相关。相反,喝水、果汁或牛奶与GER症状无关。喝水代替咖啡、茶或苏打水可以降低GER症状的风险。

医务人员经常建议患者不要接触咖啡、茶和/或苏打水,以减轻食管反流(GER)的症状,例如烧心或反流。但是,没有前瞻性研究的数据支持这些建议。近日,消化病领域权威杂志Clinical Gastroenterology and Hepatology发表了一篇研究文章,研究人员从前瞻性护士健康研究II中收集了48308名42-62岁的女性的数据,这些女性没有规律的GER症状,没有癌症,也没有服用质子泵抑制剂或H2受体激动剂。

研究人员使用多变量Cox比例风险模型评估饮料摄入量与GER症状风险之间的相关性。在262641人次每年的随访期间,研究人员确定了7961名每周报告一次或多次GER症状的女性。

经过多变量调整后,与每种饮料摄入量最低(0份/天)的女性相比,摄入量最高(超过6份/天)的女性的风险比(HRs)分别为:咖啡1.34(95%CI为1.13-1.59;趋势P<0.0001),茶1.26(95%CI为1.03-1.55;趋势P<0.001),苏打水1.29(95%CI为1.05-1.58;趋势P<0.0001)。根据咖啡因状态对患者进行分层时,研究人员得到了相似的结果。牛奶、水或果汁的摄入与GER症状的风险之间没有关联。在替代分析中,每天用2份水代替2份咖啡、茶或苏打水可降低GERD症状的风险:咖啡HR为0.96(95%CI为0.92-1.00);茶HR为0.96(95%CI为0.92-1.00); 苏打水HR为0.92(95%CI为0.89-0.96)。

由此可见,这项前瞻性护士健康研究II数据分析表明咖啡、茶或苏打水的摄入与GER症状风险增加相关。相反,喝水、果汁或牛奶与GER症状无关。喝水代替咖啡、茶或苏打水可以降低GER症状的风险。  

原始出处:

Raaj S. Mehta,et al.Association Between Beverage Intake and Incidence of Gastroesophageal Reflux Symptoms Beverages and GER symptoms.Clinical gastroenterology and hepatology.2019.https://www.cghjournal.org/article/S1542-3565(19)31380-1/fulltext

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    2020-08-06 许安
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    2019-12-02 feifers

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