Hypertension:高血压患者慢波睡眠与阻塞性睡眠呼吸暂停之间的相互作用

2019-12-24 xing.T MedSci原创

由此可见,SWS的效应很可能受到OSA严重性的调节。SWS可能与OSA患者表现出的心血管疾病高发风险有关。

由于频繁的异常呼吸事件及其对睡眠结构的影响,阻塞性睡眠呼吸暂停(OSA)患者的慢波睡眠(SWS)数量减少。在社区研究中,减少的SWS与高血压有关。近日,心血管权威杂志Hypertension上发表了一篇研究文章,研究人员试图调查SWS百分比是否能改变OSA与高血压之间的关联。

研究人员探究了7107例OSA患者和1118例经过实验室多导睡眠图检查的原发性打鼾者。根据患者SWS百分比的四分位数分组。高血压是根据临床血压测量或医师诊断来定义。

多变量logistic回归模型显示OSA和SWS对高血压患病率具有显著的交互作用(P=0.002)。SWS降低与OSA患者发生高血压的几率更高相关,而在原发性打鼾者中则不相关,SWS<0.1%(OR为1.44[95%CI为1.21-1.70];P=0.001)和0.1%至4.8%(OR为1.20 [95%CI为1.03-1.40];P=0.02)的OSA患者,与SWS>11.1%的人群相比,更有可能患有高血压。在按OSA严重性分层的分析中,仅在中度和严重OSA患者中,SWS百分比与血压之间存在显著关联。性别(P=0.040)和年龄(P=0.007)的效果修饰仅在OSA患者中明显,这表明SWS降低仅与男性和<60岁患者的高血压相关。SWS降低与OSA患者高血压的患病几率呈剂量依赖性增加。 

由此可见,SWS的效应很可能受到OSA严重性的调节。SWS可能与OSA患者表现出的心血管疾病高发风险有关。

原始出处:

Rong Ren.et al.Interaction Between Slow Wave Sleep and Obstructive Sleep Apnea in Prevalent Hypertension.Hypertension.2019.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.13720

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  6. 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  7. 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03:40:00 CST 2019, time=2019-12-26, status=1, ipAttribution=)]
    2019-12-26 ylz8405
  8. 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