FASEB J：振奋人心！新的研究发现或可为神经性疼痛的治疗带来新的希望！

2017-05-02 MedSci MedSci原创

近期来自日本的一项新的研究表明，一种靶向LPCAT2的新的治疗或可有效对抗目前尚无法解决的疼痛，这项研究还揭示了血小板活化因子（PAF）的疼痛循环的存在，提示PAF受体拮抗剂可能发挥的作用，该研究结果已发表于FASEB Journal 。研究人员使用动物实验就行验证，将小鼠分为两组。第一组（LPCAT2-KO小鼠）破坏LPCAT2基因，LPCAT2通常编码合成PAF。另一组为正常小鼠。然后研究人员

近期来自日本的一项新的研究表明，一种靶向LPCAT2的新的治疗或可有效对抗目前尚无法解决的疼痛，这项研究还揭示了血小板活化因子（PAF）的疼痛循环的存在，提示PAF受体拮抗剂可能发挥的作用，该研究结果已发表于FASEB Journal 。

研究人员使用动物实验就行验证，将小鼠分为两组。第一组（LPCAT2-KO小鼠）破坏LPCAT2基因，LPCAT2通常编码合成PAF。另一组为正常小鼠。然后研究人员结扎两组小鼠坐骨神经结扎（PSL）诱导建立神经病理性疼痛模型。

结果发现，PSL手术增加了WT小鼠的疼痛行为，但是在LPCAT2-KO小鼠中却并未出现。该研究结果表明，或可通过研发抑制PAF生物合成酶——LPCAT2，来治疗神经性疼痛，以及对LPCAT拮抗剂的再评估。

该研究结果着实令人兴奋，或为神经性疼痛的治疗带来新的希望，研究人员希望该研究发现或可为所有患有神经性疼痛的患者带来新的治疗方案。

原始出处：

Shindou H, Shiraishi S, et al., Relief from neuropathic pain by blocking of the platelet-activating factor-pain loop. FASEB J. 2017 Mar 24. pii: fj.201601183R. doi: 10.1096/fj.201601183R.

Scientists discover new category of analgesic drugs that may treat neuropathic pain. MNT, 31 March 2017.

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2017-08-07 hywen7326

#神经性#

28 0
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2017-08-08 gracezdd

#FAS#

29 0
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2018-03-04 hanhaisha2020

#研究发现#

27 0
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2017-05-11 chenxh201314

厉害，可是用到临床才行

62 0
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2017-05-08 珍珍superwoman

学习了

70 0
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2017-05-07 珍珍superwoman

学习了

60 0
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2017-05-05 珍珍superwoman

学习了

63 0
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2017-05-04 往日如昨

学习了谢谢分享

64 0
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2017-05-04 tm10051981

#神经性疼痛#

39 0
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2017-05-02 九九消寒

优质资源，共同学习

21 0

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麻醉疼痛科

FASEB J：振奋人心！新的研究发现或可为神经性疼痛的治疗带来新的希望！

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