Ann Neurol:端粒长度与多发性硬化症的残疾进展有关

2019-09-11 xing.T MedSci原创

由此可见,短期端粒长度与残疾相关,与实际年龄无关,提示生物衰老可能导致MS的神经损伤。针对衰老相关机制是预防MS进展的潜在治疗策略。

近日,神经病学领域权威取杂志Annals of Neurology上发表了一篇研究文章,研究人员旨在评估通过白细胞端粒长度(LTL)衡量的生物衰老是否与多发性硬化症(MS)患者的临床残疾和脑容量损失相关。

研究人员纳入了UCSF-EPIC队列研究中的MS/CIS成人,通过定量PCR测量了DNA样品上LTL,并以端粒与体细胞DNA比率(T/S)来表示。在基线和随访时填写扩展残疾状态量表(EDSS),并进行3D T1加权脑MRI检查。研究人员使用简单和混合效应线性回归模型评估基线LTL与横断面和纵向患者结局之间的关联。一个亚组(n=46)随时间的变化测量了LTL,研究人员采用混合效应模型评估了LTL变化与EDSS变化之间的关系。

在纳入了356名女性和160名男性(平均年龄为43岁,中位疾病持续时间为6年,中位数EDSS为1.5(范围0-7),平均T/S比为0.97(SD为0.18))。在根据年龄、疾病持续时间和性别调整的基线分析中,LTL每降低0.2,EDSS增加0.27(95%CI为0.13-0.42,p<0.001),脑容量减少7.4mm3(0.10-14.7,p=0.047) 。在纵向调整分析中,基线LTL较低的患者随着时间的推移具有较高的EDSS和较低的脑容量。在该亚组的调整分析中,LTL变化与10年内EDSS变化相关:LTL每降低0.2,EDSS增加0.34(0.08-0.61,p=0.012)。

由此可见,短期端粒长度与残疾相关,与实际年龄无关,提示生物衰老可能导致MS的神经损伤。针对衰老相关机制是预防MS进展的潜在治疗策略。 

原始出处:

Kristen M. Krysko,et al.Telomere length is associated with disability progression in multiple sclerosis.Annals of Neurology. 2019.https://onlinelibrary.wiley.com/doi/10.1002/ana.25592

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    2020-01-22 yinhl1978
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    2020-07-22 jml2009
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