BJC:宫内暴露于电离辐射,会增加后代血液系统恶性肿瘤风险

2016-11-21 MedSci MedSci原创

子宫内暴露于低剂量的电离辐射是否会增加血液系统恶性肿瘤的终生风险?目前仍不清楚。 我们合并了两个队列的数据:来自乌拉尔南部大型核设施的女性工人后代,生活在核事故/垃圾污染的捷恰河周围的的女性后代。有详细的剂量学数据。 队列合并后共有19 536例参与者,共计700 504人年的随访时间,随访最高到61岁,共发生了58例血液系统恶性肿瘤事件和36例死亡事件。 子宫内暴露于电离辐射的

子宫内暴露于低剂量的电离辐射是否会增加血液系统恶性肿瘤的终生风险?目前仍不清楚。

我们合并了两个队列的数据:来自乌拉尔南部大型核设施的女性工人后代,生活在核事故/垃圾污染的捷恰河周围的的女性后代。有详细的剂量学数据。

队列合并后共有19 536例参与者,共计700 504人年的随访时间,随访最高到61岁,共发生了58例血液系统恶性肿瘤事件和36例死亡事件。

子宫内暴露于电离辐射的剂量大于等于80 mGy时,血液系统恶性肿瘤的终生风险增加(超额相对风险(ERR): 1.27; 95% CI: −0.20 to 4.71);子宫内持续暴露于100 mGy的电离辐射时,血液系统恶性肿瘤的终生风险增加(ERR: 0.77; CI: 0.02 to 2.56)。

基于死亡率的分析,没有发现子宫内暴露于电离辐射与死亡风险之间的联系。

针对白血病和淋巴瘤的分析结果,得到相似的结论。

产后暴露于电离辐射与血液系统恶性肿瘤发生率之间具有非常弱的正相关关系。

总之,研究结果表明,子宫内暴露于电离辐射与血液系统恶性肿瘤风险之间存在积极的关系;但样本量小、发病率和死亡率的相关分析得出不一致的结论,在以后还需要更多的研究来验证该结果。

原始出处:


Joachim Schüz1, Isabelle Deltour1, Lyudmila Y Krestinina2,et al.In utero exposure to radiation and haematological malignancies: pooled analysis of Southern Urals cohorts.British Journal of Cancer advance online publication 17 November 2016

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    2016-11-23 jiyangfei