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CIRC RES：主动脉瓣发育发现新信号通路！

2017-12-23 MedSci MedSci原创

心血管主动脉瓣
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主动脉瓣膜疾病是一个细胞介导的过程，并且缺乏有效的药物治疗。C型钠尿肽（CNP）可以减少瓣膜间质细胞（VICs）的纤维生成和骨生成，其在狭窄的主动脉瓣膜中表达量降低，然而CNP信号通路是否在体内调节主动脉瓣生成尚属未知。本研究的目的旨在评估CNP信号通路的缺失是否会加快主动脉瓣膜疾病的进展。在猪主动脉瓣间质细胞中，CNP可以通过鸟苷酸环化酶钠尿肽受体2（NPR2）抑制病理分化。在Npr2+/-小鼠

主动脉瓣膜疾病是一个细胞介导的过程，并且缺乏有效的药物治疗。C型钠尿肽（CNP）可以减少瓣膜间质细胞（VICs）的纤维生成和骨生成，其在狭窄的主动脉瓣膜中表达量降低，然而CNP信号通路是否在体内调节主动脉瓣生成尚属未知。本研究的目的旨在评估CNP信号通路的缺失是否会加快主动脉瓣膜疾病的进展。在猪主动脉瓣间质细胞中，CNP可以通过鸟苷酸环化酶钠尿肽受体2（NPR2）抑制病理分化。在Npr2+/-小鼠的成纤维细胞中，纤维生成对CNP敏感，且年长的Npr2+/- 和Npr2+/-；Ldlr-/-转基因小鼠出现有心功能不全和心室纤维化，与同窝野生型对照小鼠相比，Npr2+/- 和Npr2+/-；Ldlr-/-转基因小鼠的主动脉瓣功能明显受损。9.4%的Npr2+/-小鼠出现有二叶主动脉瓣（BAV），并伴有主动脉瓣膜功能受损、增厚和钙化。此外，环磷酸鸟苷依赖性蛋白激酶（cGK）的活性在Npr2+/-小鼠的主动脉瓣膜中下调。研究结果显示，CNP/NPR2是主动脉瓣膜发育过程中的一个新的信号通路。原始出处：Mark C et al.Deficiency of Natriuretic Peptide

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    2017-12-25 hittouch

    #主动脉瓣#

    0

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    2017-12-25 neurowu

    #发育#

    0

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    2017-12-25 circumcision

    #主动脉#

    0

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    2017-12-25 智者为医08

    #信号通路#

    0

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    2017-12-24 三生有幸9135

    学习一下谢谢分享

    0

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    2017-12-23 1e1b8538m79(暂无匿称)

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