J Gastroenterol Hepatol:血清胱抑素C是肝硬化腹水患者死亡风险的良好预测指标

2017-11-27 MedSci MedSci原创

血清胱抑素C是死亡和HRS-1发展的独立预测因素。胱抑素C而非血清肌酐在评估肝硬化腹水患者状态和疾病进展发面可能更有帮助。

研究背景:血清胱抑素C被认为是评估肝硬化患者肾脏功能的良好指标,然而,它的预后作用还不清楚。本研究旨在评估胱抑素C的预后作用。

研究方法:2009年9月至2013年3月,来自15家医院的肝硬化腹水患者被纳入研究分析。采用Cox回归模型分析死亡的独立危险因素和1型肝肾综合征(HRS-1)的发生的危险因素。

研究结果:最后,本研究共纳入350例患者。患者平均年龄为55.4±10.8岁,267例患者(76.3%)为男性。肝硬化的病因主要是酒精性肝病(64.3%),慢性病毒性肝炎(29.7%)。血清肌酐和胱抑素C水平分别是0.9 ±0.4 mg/dL和1.1±0.5 mg/L。多元分析表明,国际标准化比率(INR),血清胆红素,血清钠离子水平是死亡独立的相关因素。INR,血清钠离子,血清胱抑素C水平是HRS-1发展的独立预测因素。多元分析表明,血清肌酐水平与死亡和HRS-1没有相关性。

研究结论:血清胱抑素C是死亡和HRS-1发展的独立预测因素。胱抑素C而非血清肌酐在评估肝硬化腹水患者状态和疾病进展发面可能更有帮助。

原始出处

Seo YS, Park SY, Kim MY, et al. Serum cystatin C level is an excellent predictor of mortality in patients with cirrhotic ascites. J Gastroenterol Hepatol, 2017 Sep 14. doi: 10.1111/jgh.13983.

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    2018-09-19 许安
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time=2017-11-27, status=1, ipAttribution=)]
    2017-11-29 gwc384
  9. 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time=2017-11-27, status=1, ipAttribution=)]
    2017-11-27 清风拂面

    学习了.谢谢分享

    0

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