Gastroenterology:炎症性肠病患者脑-肠相互作用的双向性

2018-01-23 zhangfan MedSci原创

通过2年的随访证实,克罗恩病或溃疡性结肠炎患者病情与精神情绪心理障碍存在双向作用。对于炎症性肠病患者,心理状态监控和治疗与IBD疾病控制同样重要

炎症性肠病(IBD)与焦虑或抑郁等情绪障碍有关。近日研究人员开展为期2年的纵向前瞻性研究,考察患者IBD病情与情绪心理障碍之间的双向作用。

405名成年克罗恩病(CD)或溃疡性结肠炎(UC)患者参与研究。基线考察参与者的人口学特征、IBD亚型、治疗、症状、躯体化和粪便钙卫蛋白水平。利用Harvey-Bradshaw指数考察CD疾病活性,利用单纯临床结肠炎活动指数考察UC疾病活性,利用医院焦虑抑郁评估表(HADS)考察参与者焦虑及抑郁病情,对患者的特点和随访时间进行多因素Cox回归控制。

研究发现,基线CD或UC病情活动状态导致异常焦虑评分风险提高6倍(HR,5.77;95% CI,1.89-17.7)。对于基线非活性IBD患者,基线异常焦虑评分与随访期间糖皮质激素处方、IBD复发 (HR,2.08;95% CI,1.31-3.30)或治疗升级相关(HR,1.82;95% CI,1.19-2.80)。

通过2年的随访证实,克罗恩病溃疡性结肠炎患者病情与精神情绪心理障碍存在双向作用。对于炎症性肠病患者,心理状态监控和治疗与IBD疾病控制同样重要。

原始出处:

David J. Gracie et al. Bi-directionality of Brain-Gut Interactions in Patients With Inflammatory Bowel Diseases. Gastroenterology. January 21, 2018.

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    2018-11-14 zhaojie88
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    2018-01-27 lofter

    学习了感谢分享

    0

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    2018-01-25 ylz8405
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