Plos One:别再让食品污染事件伤害儿童了!

2017-04-17 MedSci MedSci原创

2011年5月,台湾发生涉及邻苯二甲酸酯类污染食品的重大事件,将邻苯二甲酸二(2-乙基己基)酯(DEHP)加入到食品中,主要是果汁、果冻、茶、运动饮料和膳食补充剂。令人担忧的是,正常的青春期发育,特别是儿童的生殖激素调节可能被DEHP打乱。近期,一项发表在杂志PLos One上的研究调查了邻苯二甲酸酯暴露与接触邻苯二甲酸酯污染的食物后,儿童生殖激素水平的变化情况。事件发生后,共招募了台北北部、中部

2011年5月,台湾发生涉及邻苯二甲酸酯类污染食品的重大事件,将邻苯二甲酸二(2-乙基己基)酯(DEHP)加入到食品中,主要是果汁、果冻、茶、运动饮料和膳食补充剂。令人担忧的是,正常的青春期发育,特别是儿童的生殖激素调节可能被DEHP打乱。


近期,一项发表在杂志PLos One上的研究调查了邻苯二甲酸酯暴露与接触邻苯二甲酸酯污染的食物后,儿童生殖激素水平的变化情况。

事件发生后,共招募了台北北部、中部和南部3家医院的239名12岁以下儿童。用结构化问卷调查收集5类邻苯二甲酸酯污染食品的饮用的频率和数量,以评估儿童接触邻苯二甲酸酯的暴露情况。

收集受试儿童的尿样用于测量邻苯二甲酸酯代谢物水平。在发生污染事件发生时估计每日摄入DEHP的摄入量是使用问卷数据和尿DEHP代谢浓度计算的。应用多元回归分析来评估邻苯二甲酸酯暴露与儿童生殖激素水平之间的联系。

此项研究结果显示:在排除有关暴露水平和激素浓度缺失数据的儿童和月经女孩之后,共有222名儿童被纳入统计分析。调整年龄和出生体重后,邻苯二甲酸尿酸单酯(2-乙基-5-羟基己基),邻苯二甲酸单酯(2-乙基-5-氧己基)和中间体的单邻苯二甲酸酯(2-乙基己基) )的浓度高于中位卵泡刺激素的浓度。高于中位数水平之后,平均每日接受DEHP暴露量的女孩在性别激素结合球蛋白的中位数水平上也有较高的几率。

此项研究结果表明:邻苯二甲酸盐暴露与女孩生殖激素水平的变化有关。

原始出处:
Wen H, Chen CC, et al. Phthalate exposure and reproductive hormones and sex-hormone binding globulin before puberty - Phthalate contaminated-foodstuff episode in Taiwan. PLoS One. 2017 Apr 14;12(4):e0175536. doi: 10.1371/journal.pone.0175536. eCollection 2017.

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    2017-04-18 ylzr123

    不错的方式,努力学习,刻苦专研,不断总结出来新经验。

    0

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    2017-04-17 cuiyejia

    学习了,谢谢

    0

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    2017-04-17 1dd8aa01m06(暂无匿称)

    学习了很好的内容

    0

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    2017-04-17 doctorJiangchao

    继续关注。

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