Diabet Med:无论有没有GDM,超重/肥胖都会增加剖宫产、子痫前期和大于胎龄儿的风险

2016-07-09 Seven L 译 MedSci原创

肥胖的妊娠期糖尿病孕妇与正常体重高的非妊娠糖尿病孕妇相比,剖宫产、先兆子痫和大于胎龄儿的风险更大,不过近期的研究也表明,不管孕妇有没有妊娠糖尿病,超重和肥胖增加以上提到的风险。瑞典Örebro大学医学与健康科学学院的Karin Hilden博士和同事分析了1249908例孕妇BMI至少18.5 kg/m²的单胎妊娠情况,1型或2型糖尿病的女性被排除在外。获取了母亲的人口数据、孕期并发症,以及分娩和

肥胖的妊娠期糖尿病孕妇与正常体重高的非妊娠糖尿病孕妇相比,剖宫产、先兆子痫和大于胎龄儿(LGA)的风险更大,不过近期的研究也表明,不管孕妇有没有妊娠糖尿病,超重和肥胖增加以上提到的风险。

瑞典Örebro大学医学与健康科学学院的Karin Hilden博士和同事分析了1249908例孕妇BMI至少18.5 kg/m²的单胎妊娠情况,1型或2型糖尿病的女性被排除在外。获取了母亲的人口数据、孕期并发症,以及分娩和新生儿等相关数据。75克口服葡萄糖耐量试验确定孕妇是否患有妊娠期糖尿病。

在队列中,有13057名孕妇(1%)被诊断为妊娠糖尿病,其中38.1%的孕妇肥胖。

研究人员发现,肥胖(BMI≥30 kg/m²)的妊娠期糖尿病孕妇有最高的不良预后风险,校正年龄、吸烟、高血压病、胎次、国家等因素后,剖宫产风险OR=2.68 (95% CI, 2.52-2.85),子痫前期风险OR=6.45 (95% CI, 5.82-7.14),大于胎龄儿风险OR=6.5 (95% CI, 6.1-6.92)。

正常体重的妊娠期糖尿病女性其以上风险也增加:剖宫产 OR = 1.26; 95% CI, 1.16-1.37、子痫前期 OR = 2.03; 95% CI, 1.71-2.41、大于胎龄儿 OR = 2.25; 95% CI, 2.06-2.46。

没有妊娠期糖尿病的超重女性以上风险同样增高:剖宫产 OR = 1.34; 95% CI, 1.33-1.36、子痫前期 OR = 1.76; 95% CI, 1.72-1.81、大于胎龄儿 OR = 1.76; 95% CI, 1.74-1.79。

研究人员写道:“目前全国范围的研究表明,无论孕妇有和无妊娠糖尿病,超重和肥胖与剖宫产、子痫前期和大于胎龄儿的风险增加有关。”

原始出处:

Hildén K, et al. Overweight and obesity: a remaining problem in women treated for severe gestational diabetes.Diabet Med. 2016;doi:10.1111/dme.13156.

Gestational diabetes, obesity increase risk for adverse maternal, neonatal outcomes.Healio.July 8, 2016


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href='/topic/show?id=097a452219b' target=_blank style='color:#2F92EE;'>#子痫前期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45221, encryptionId=097a452219b, topicName=子痫前期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Mon Jul 11 01:41:00 CST 2016, time=2016-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404387, encodeId=415b140438e74, content=<a href='/topic/show?id=db62e905e8' target=_blank style='color:#2F92EE;'>#GDM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7905, encryptionId=db62e905e8, topicName=GDM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=330f2470752, createdName=朱睿睿, createdTime=Mon Jul 11 01:41:00 CST 2016, time=2016-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606979, encodeId=995316069e9c5, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Jul 11 01:41:00 CST 2016, time=2016-07-11, status=1, ipAttribution=)]
    2016-09-21 1e10c84am36(暂无匿称)

    文章很好,非常有益

    0

  5. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606979, encodeId=995316069e9c5, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Jul 11 01:41:00 CST 2016, time=2016-07-11, status=1, ipAttribution=)]
    2016-09-13 舒心和人

    看来控制体重对于任何时候的人来说都是很有益处的,感谢分享

    0

  6. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606979, encodeId=995316069e9c5, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Jul 11 01:41:00 CST 2016, time=2016-07-11, status=1, ipAttribution=)]
    2016-09-10 ylzr123

    关注并学习。赞!好文。

    0

  7. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Sep 10 17:09:00 CST 2016, time=2016-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809489, encodeId=77ae180948947, content=<a href='/topic/show?id=c9f18368966' target=_blank style='color:#2F92EE;'>#胎龄儿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83689, encryptionId=c9f18368966, topicName=胎龄儿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=82ba2500166, createdName=ms1467340776200723, createdTime=Wed Mar 22 05:41:00 CST 2017, time=2017-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366544, encodeId=5498136654476, content=<a href='/topic/show?id=097a452219b' target=_blank style='color:#2F92EE;'>#子痫前期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45221, encryptionId=097a452219b, topicName=子痫前期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Mon Jul 11 01:41:00 CST 2016, time=2016-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404387, encodeId=415b140438e74, content=<a href='/topic/show?id=db62e905e8' target=_blank style='color:#2F92EE;'>#GDM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7905, encryptionId=db62e905e8, topicName=GDM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=330f2470752, createdName=朱睿睿, createdTime=Mon Jul 11 01:41:00 CST 2016, time=2016-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606979, encodeId=995316069e9c5, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Jul 11 01:41:00 CST 2016, time=2016-07-11, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1759706, encodeId=7c3b1e5970664, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sun Apr 30 21:41:00 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1740309, encodeId=56741e4030912, content=<a href='/topic/show?id=f9f383688d0' target=_blank style='color:#2F92EE;'>#胎龄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83688, encryptionId=f9f383688d0, topicName=胎龄)], attachment=null, authenticateStatus=null, createdAvatar=null, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Sep 10 17:09:00 CST 2016, time=2016-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809489, encodeId=77ae180948947, content=<a href='/topic/show?id=c9f18368966' target=_blank style='color:#2F92EE;'>#胎龄儿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83689, encryptionId=c9f18368966, topicName=胎龄儿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=82ba2500166, createdName=ms1467340776200723, createdTime=Wed Mar 22 05:41:00 CST 2017, time=2017-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366544, encodeId=5498136654476, content=<a href='/topic/show?id=097a452219b' target=_blank style='color:#2F92EE;'>#子痫前期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45221, encryptionId=097a452219b, topicName=子痫前期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Mon Jul 11 01:41:00 CST 2016, time=2016-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404387, encodeId=415b140438e74, content=<a href='/topic/show?id=db62e905e8' target=_blank style='color:#2F92EE;'>#GDM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7905, encryptionId=db62e905e8, topicName=GDM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=330f2470752, createdName=朱睿睿, createdTime=Mon Jul 11 01:41:00 CST 2016, time=2016-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606979, encodeId=995316069e9c5, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Jul 11 01:41:00 CST 2016, time=2016-07-11, status=1, ipAttribution=)]
    2016-07-11 yahu
  9. [GetPortalCommentsPageByObjectIdResponse(id=1759706, encodeId=7c3b1e5970664, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sun Apr 30 21:41:00 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1740309, encodeId=56741e4030912, content=<a href='/topic/show?id=f9f383688d0' target=_blank style='color:#2F92EE;'>#胎龄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83688, encryptionId=f9f383688d0, topicName=胎龄)], attachment=null, authenticateStatus=null, createdAvatar=null, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Sep 10 17:09:00 CST 2016, time=2016-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809489, encodeId=77ae180948947, content=<a href='/topic/show?id=c9f18368966' target=_blank style='color:#2F92EE;'>#胎龄儿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83689, encryptionId=c9f18368966, topicName=胎龄儿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=82ba2500166, createdName=ms1467340776200723, createdTime=Wed Mar 22 05:41:00 CST 2017, time=2017-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366544, encodeId=5498136654476, content=<a href='/topic/show?id=097a452219b' target=_blank style='color:#2F92EE;'>#子痫前期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45221, encryptionId=097a452219b, topicName=子痫前期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Mon Jul 11 01:41:00 CST 2016, time=2016-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404387, encodeId=415b140438e74, content=<a href='/topic/show?id=db62e905e8' target=_blank style='color:#2F92EE;'>#GDM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7905, encryptionId=db62e905e8, topicName=GDM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=330f2470752, createdName=朱睿睿, createdTime=Mon Jul 11 01:41:00 CST 2016, time=2016-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606979, encodeId=995316069e9c5, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Jul 11 01:41:00 CST 2016, time=2016-07-11, status=1, ipAttribution=)]
    2016-07-11 朱睿睿
  10. 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