Gut:胃食管反流症状的全球患病情况和危险因素

2017-02-26 xing.T MedSci原创

由此可见,胃食管反流症状的发生率在国家之间存在明显的不同,即使采用类似的定义来定义胃食管反流症状的存在。在年龄≥50岁、吸烟者、非甾体抗炎药使用者和肥胖的个体中患病率较高,虽然这些相关性较为中等。

胃食管反流症状在社区人群中很是常见,但一直没有明确的针对所有估计胃食管反流症状全球患病率或该病潜在的危险因素的研究数据进行系统评价和荟萃分析。近日,消化病领域权威杂志gut上发表了一篇针对这一问题的荟萃分析文章。

研究人员通过检索MEDLINE、EMBASE和EMBASE经典数据库(检索时间直到2016年9月),确定了报道了成人(≥15岁)胃食管反流症状发生率以人群为基础的研究;胃食管反流的确诊是通过使用基于症状的标准或问卷来完成。研究人员从所有研究中提取患病率,并根据使用的标准来进行定义。根据研究的位置和其他一些特点,将患病率进行合并,并计算比值比和95%可信区间。

研究人员评估了14132篇文献,有102篇文献在108个不同的研究人群中报道了胃食管反流症状的发生率,含有460984例患者。患病率根据国家(从中国的2.5%到希腊的51.2%)和用来确定胃食管反流症状的标准而有所不同。只有当研究采用每周烧心或反流频率来定义胃食管反流症状才被考虑,合并的患病率为13.3%(95%可信区间为12%-14.6%)。在年龄≥50岁(比值比为1.32;95%可信区间为1.12-1.54)、吸烟者(比值比为1.26;95%可信区间为1.04-1.52)、非甾体类抗炎药(NSAID)/阿司匹林使用者(比值比为1.44;95%可信区间为1.10-1.88)和肥胖(比值比为1.73;95%可信区间为1.46-2.06)的受试者中患病率较高。

由此可见,胃食管反流症状的发生率在国家之间存在明显的不同,即使采用类似的定义来定义胃食管反流症状的存在。在年龄≥50岁、吸烟者、非甾体抗炎药使用者和肥胖的个体中患病率较高,虽然这些相关性较为中等。

原始出处:

Leonardo H Eusebi, et al. Global prevalence of, and risk factors for, gastro-oesophageal reflux symptoms: a meta-analysis. Gut. 2016. http://dx.doi.org/10.1136/gutjnl-2016-313589

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    2017-02-28 zhouqu_8
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    2017-02-28 feifers
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    2017-02-27 往日如昨

    年龄≥50岁、吸烟者、非甾体抗炎药使用者和肥胖的个体中胃食管反流症状的发生率较高

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