ANN ONCOL:trabectedin治疗老年软组织肉瘤患者的有效性和耐受性

2018-09-29 MedSci MedSci原创

由于治疗相关的毒性风险增加,对于年龄≥65岁的软组织肉瘤(STS)患者的治疗选择有限。蒽环类化疗失败后,Trabectedin可以改善晚期脂肪肉瘤或平滑肌肉瘤患者的疾病控制情况。既往研究表明,无论患者年龄如何,trabectedin具有相似的安全性和治疗效果。ANN ONCOL近期发表了一篇文章,对参加ET743-SAR-3007试验的老年患者进行了亚组分析。

由于治疗相关的毒性风险增加,对于年龄≥65岁的软组织肉瘤(STS)患者的治疗选择有限。蒽环类化疗失败后,Trabectedin可以改善晚期脂肪肉瘤或平滑肌肉瘤患者的疾病控制情况。既往研究表明,无论患者年龄如何,trabectedin具有相似的安全性和治疗效果。ANN ONCOL近期发表了一篇文章,对参加ET743-SAR-3007试验的老年患者进行了亚组分析。

患者以3:1的比例随机分为两组,一组接受trabectedin治疗(n ?= 384),另一组接受达卡巴嗪治疗(n ?= 193)。主要研究终点是总生存期(OS),次要研究终点包括无进展生存期(PFS),出现进展时间,客观反应率(ORR),反应持续时间,症状严重程度和安全性。研究结果表明,在131名(trabectedin 组= 94; 达卡巴嗪组 = 37)老年患者中,接受trabectedin治疗的患者与接受达卡巴嗪治疗的患者相比治疗暴露时间更长,trabectedin组接受长期治疗(≥6个周期)的比例更高(分别为43%和23%)。接受trabectedin治疗的老年患者PFS显着改善,但OS或ORR无显着改善。老年患者接受trabectedin治疗的安全性与整体研究人群的安全性相当。

文章最后认为,对ET743-SAR-3007试验中老年人群的亚组分析表明,老年STS患者可以从trabectedin治疗中得到临床获益。

原始出处:

R L Jones  G D Demetri,et al. Efficacy and tolerability of trabectedin in elderly patients with sarcoma: subgroup analysis from a phase III, randomized controlled study of trabectedin or dacarbazine in patients with advanced liposarcoma or leiomyosarcoma. ANN ONCOL.September 2018 doi: https://doi.org/10.1093/annonc/mdy253

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    2019-09-15 aliceclz
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    2019-04-22 minlingfeng
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    2018-11-11 bsmagic9140
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    2018-10-01 qilu_qi

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