Sci Rep:鳞状/腺体组织学变异高风险NMIBC的BCG滴注与根治性膀胱切除术比较

2019-11-12 AlexYang MedSci原创

最近,有研究人员评估了卡介苗(BCG)滴注与根治性膀胱切除术对鳞状/腺体组织学变异高风险NMIBC的治疗效果情况。研究人员回顾了高风险NMIBC患者的数据,数据的时间为2000年1月到2017年12月。他们对鳞状/腺体组织学变异高风险NMIBC患者的根治性膀胱切除术治疗、膀胱内卡介苗治疗和观察组进行了比较分析。研究共包括了1263名高风险NMIBC患者,其中62名(4.9%)报道具有鳞状/腺体组织

最近,有研究人员评估了卡介苗(BCG)滴注与根治性膀胱切除术对鳞状/腺体组织学变异高风险NMIBC的治疗效果情况。

研究人员回顾了高风险NMIBC患者的数据,数据的时间为2000年1月到2017年12月。他们对鳞状/腺体组织学变异高风险NMIBC患者的根治性膀胱切除术治疗、膀胱内卡介苗治疗和观察组进行了比较分析。研究共包括了1263名高风险NMIBC患者,其中62名(4.9%)报道具有鳞状/腺体组织学变异。30名患者经历了BCG滴注,15名患者进行了根治性膀胱切除术。研究人员癌3个治疗组中的高血压(p=0.031)、T期(p=0.022)和肿瘤多样性(p=0.019)方面发现了统计学显著差异。而在BCG滴注组和根治性膀胱切除组中5年OS(p=0.893)和CSS (p=0.811)相似。另外,BCG滴注组表现出了相比观察组的OS (p=0.019)和CSS (p=0.038)生存益处。在诊断为鳞状/腺体组织学变异高风险NMIBC膀胱癌的患者中,膀胱内卡介苗滴注和根治性膀胱切除术均能够展现出生存益处。

最后,研究人员指出,BCG滴注是鳞状/腺体组织学变异高风险NMIBC的一种合适的治疗方法。

原始出处:

Jungyo Suh, Kyung Chul Moon, Jae Hyun Jung et al. BCG instillation versus radical cystectomy for high-risk NMIBC with squamous/glandular histologic variants. Sci Rep. 24 Oct 2019

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    2019-11-14 jeanqiuqiu

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