Eur Radiol:冠状动脉CTA在显示OCT定义的薄帽的纤维粥样斑块特点的价值

2017-08-27 shaosai MedSci原创

易损斑块(Vulnerable Plaque)是指那些不稳定和有血栓形成倾向的斑块,主要包括破裂斑块、侵蚀性斑块和部分钙化结节性病变。本研究旨在评价利用冠状动脉CTA(CCTA)显示的斑块特征是否与薄帽地纤维粥样斑块(TCFA)的出现具有相关性,后者是一种光学相干断层成像技术定义的斑块破裂的先兆,并将结果发表在Eur Radiol上。

易损斑块(Vulnerable Plaque)是指那些不稳定和有血栓形成倾向的斑块,主要包括破裂斑块、侵蚀性斑块和部分钙化结节性病变。本研究旨在评价利用冠状动脉CTA(CCTA)显示的斑块特征是否与薄帽地纤维粥样斑块(TCFA)的出现具有相关性,后者是一种光学相干断层成像技术定义的斑块破裂的先兆,并将结果发表在Eur Radiol上。

本研究共纳入了28例具有症状的患者共31处冠状动脉病变,并分析727层联合CCTA和OCT的血管断面。CCTA上斑块特点主要包括低密度斑块(LAP, <30 HU),餐巾环征(NRS)、正性重构(PR, 重构指数≥1.10)、点状钙化、斑块面积和斑块负荷。利用OCT来鉴别有无TCFA、管腔面积、脂质。

在OCT中,共有19处病变(61.2 %)69层(9.4%)出现了TCFA。在每层的分析中,与无OCT-TCFA的参与相比,OCT-TCFA检出CCTA发现的LAP(58.0% vs. 18.5%)、NRS(31.9% vs. 8.8%)、PR(68.1% vs. 48.0%)更高,斑块负荷更加严重(70.6% vs. 61.9%)(所有p< 0.05)。在多变量分析中,LAP(odds ratio [OR] 4.05, p < 0.001)、NRS(OR 2.47, p = 0.005)与OCT-TCFA具有相关性。CCTA测量的管腔面积与OCT测量的管腔面积具有良好的相关性(R = 0.859, limits of agreement -0.5 ± 3.7 mm 2)。

本研究表明,在每层血管断面分析中CCTA的LAP和NRS与OCT定义的TCFA具有相关性。

原始出处:

Yang DH, Kang SJ, Koo HJ, et al,Coronary CT angiography characteristics of OCT-defined thin-cap fibroatheroma: a section-to-section comparison study. Eur Radiol. 2017.DOI: 10.1007/s00330-017-4992-8

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    2018-05-01 仁医06
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    2017-09-29 habb
  5. [GetPortalCommentsPageByObjectIdResponse(id=2019785, encodeId=d9432019e85ff, content=<a href='/topic/show?id=6c3ce629914' target=_blank style='color:#2F92EE;'>#粥样斑块#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76299, encryptionId=6c3ce629914, topicName=粥样斑块)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Tue Sep 19 01:25:00 CST 2017, time=2017-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849548, encodeId=af9118495484b, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Tue May 01 21:25:00 CST 2018, time=2018-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1708784, encodeId=584a1e08784be, content=<a href='/topic/show?id=989d308399f' target=_blank style='color:#2F92EE;'>#冠状动脉CT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30839, encryptionId=989d308399f, topicName=冠状动脉CT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b7b31562840, createdName=1249897bm47(暂无昵称), createdTime=Tue Jun 12 22:25:00 CST 2018, time=2018-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1858320, encodeId=17301858320a2, content=<a href='/topic/show?id=21311323521' target=_blank style='color:#2F92EE;'>#OCT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13235, encryptionId=21311323521, topicName=OCT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19c567, createdName=habb, createdTime=Fri Sep 29 23:25:00 CST 2017, time=2017-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330058, encodeId=85a8133005835, content=<a href='/topic/show?id=a91c5e92328' target=_blank style='color:#2F92EE;'>#斑块#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57923, encryptionId=a91c5e92328, topicName=斑块)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Tue Aug 29 08:25:00 CST 2017, time=2017-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237979, encodeId=951623e979a5, content=好好学习.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLANEL7Sww3HicKsN9aribicAmGGWXOIMEiaZ1iadgZg9RibjqSwIKUS8gSPib2NwTVg2zVvVJhdP3BkuDIl/0, createdBy=944d1605392, createdName=shaosai, createdTime=Mon Aug 28 10:18:25 CST 2017, time=2017-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237810, encodeId=aacc23e81096, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Sun Aug 27 23:31:13 CST 2017, time=2017-08-27, status=1, ipAttribution=)]
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    2017-08-28 shaosai

    好好学习.谢谢分享!

    0

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    2017-08-27 184****9840

    学习了谢谢分享

    0

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