Biomater Sci:Ag纳米管改性钛植体或可预防种植体周围炎的发生

2019-07-31 不详 网络

钛(Ti)是临床上广泛使用的植入材料;然而,由于其生物惰性和差的抗菌能力,失败仍然经常发生。植入后感染最有可能发生在植入前两周内。此后,宿主免疫系统降低了感染风险,生物安全成为首要考虑因素。因此,赋予生物医学Ti以时间依赖性杀菌效果是相当令人感兴趣的。在这项研究中,Ag纳米粒子(NPs)作为抗菌剂被深深地掺入到在喷砂和蚀刻(SLA)Ti表面上制备的TiO2纳米管中。结果证实,掺入的Ag NP自动从

钛(Ti)是临床上广泛使用的植入材料;然而,由于其生物惰性和差的抗菌能力,失败仍然经常发生。植入后感染最有可能发生在植入前两周内。此后,宿主免疫系统降低了感染风险,生物安全成为首要考虑因素。因此,赋予生物医学Ti以时间依赖性杀菌效果是相当令人感兴趣的。在这项研究中,Ag纳米粒子(NPs)作为抗菌剂被深深地掺入到在喷砂和蚀刻(SLA)Ti表面上制备的TiO2纳米管中。

结果证实,掺入的Ag NP自动从自由状态转变为固定状态,使得构建的平台表现出自调节抗菌作用。它在早期阶段表现出强烈的“释放杀菌”活性,逐渐变为“接触杀菌”能力。这种改变可以满足生物材料植入后不同时期的各种抗菌要求。此外,与商业上使用的SLA植入物相比,纳米管结构可以加速磷灰石的形成并改善细胞粘附和增殖。

基于这些结果,可以得出结论,掺入Ag-NP的微纳米结构Ti具有有价值的生物学和时间依赖性抗菌性质,并且它在骨科,牙科和其他生物医学装置的制造中具有有希望的应用。

原始出处:

Li B, Ma J, et al., Self-adjusting antibacterial properties of Ag-incorporated nanotubes on micro-nanostructured Ti surfaces. Biomater Sci. 2019 Jul 29. doi: 10.1039/c9bm00862d.

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    2019-12-11 30397613
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    2020-05-21 huangdf
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    2020-05-11 sunylz
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