Int J Cardiol:阜外医院医生发现代谢异常的正常体重人群心血管风险升高

2013-09-16 佚名 丁香园

研究要点: 1.阜外医院张伟丽等人对肥胖和代谢异常共同对心血管疾病风险和死亡率之间的联系做了研究。 2.研究结果发现体重正常但代谢异常的人群心血管风险升高,健康的超重和肥胖人群风险也增加。人们以往认为代谢正常的健康肥胖是一种良性状态,但本次研究结果对此提出了质疑。 3.研究结果发表在《国际心血管杂志》上。 体重正常、超重和肥胖的人群由于代谢异

研究要点:

1.阜外医院张伟丽等人对肥胖和代谢异常共同对心血管疾病风险和死亡率之间的联系做了研究。

2.研究结果发现体重正常但代谢异常的人群心血管风险升高,健康的超重和肥胖人群风险也增加。人们以往认为代谢正常的健康肥胖是一种良性状态,但本次研究结果对此提出了质疑。

3.研究结果发表在《国际心血管杂志》上。【原文下载】

体重正常、超重和肥胖的人群由于代谢异常的不同,心血管疾病患病风险也不同。阜外医院张伟丽等人对肥胖和代谢异常共同对心血管疾病风险和死亡率之间的联系做了研究,结果发现体重正常但代谢异常的人群心血管风险升高,研究发表于《国际心血管杂志》。

研究人员从MEDLINE、EMBASE、Cochrane图书馆和所有相关研究论文中搜索2013年5月前的前瞻性研究,所有研究均关于肥胖和代谢综合征或胰岛素抵抗两者联合作用对心血管风险和死亡的影响,根据需要选择随机效应模型或固定效应模型计算合并相对危险度(RR)和95%置信区间(CI)。

本次荟萃分析共纳入14项前瞻性试验,共计299,059名受试者,其中12,125例发生CVD事件,2130例CVD死亡,还有7071例全因死亡。与健康正常体重人群相比,代谢正常的超重人群(MHOW)和肥胖人群(MHOB)CVD事件风险增加,随访时间超过15年后,风险增加更为显著,MHOW组合MHOB组合并相对风险分别为1.47和2.00.体重正常但代谢异常的人群CVD风险和CVD相关死亡风险增加。而代谢异常的肥胖人群CVD和死亡风险最高。

研究结果发现,体重正常但代谢异常的人群CVD风险和死亡率显著增加。健康的超重和肥胖人群风险也增加,人们以往认为代谢正常的健康肥胖是一种良性状态,但本次研究结果对此提出了质疑。

原文下载

Fan J, Song Y, Chen Y, Hui R, Zhang W.Combined effect of obesity and cardio-metabolic abnormality on the risk of cardiovascular disease: A meta-analysis of prospective cohort studies.Int J Cardiol. 2013 Aug 1


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