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J Biomed Mater Res B Appl Biomater：镁涂层对有无聚醚醚酮颗粒干扰的骨-种植体界面的影响

2019-02-01 MedSci MedSci原创

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本研究探究了镁（Mg）对多孔结构界面处的成骨和骨吸收的影响。引入涂有Mg的三维（3D）印刷多孔Ti6Al4V植入物，并添加聚醚-醚-酮磨损颗粒以产生植入物松动的动物模型。我们还检测了Mg浸出液对成骨细胞/破骨细胞基因表达，碱性磷酸酶活性，胶原分泌，抗酒石酸酸性磷酸酶活性和体外骨吸收的影响。结果显示，Mg在体外和体内抑制破骨细胞分化的早期阶段并抑制骨吸收。然而，Mg在多孔结构中或在植入物周围的周边区

本研究探究了镁（Mg）对多孔结构界面处的成骨和骨吸收的影响。

引入涂有Mg的三维（3D）印刷多孔Ti6Al4V植入物，并添加聚醚-醚-酮磨损颗粒以产生植入物松动的动物模型。我们还检测了Mg浸出液对成骨细胞/破骨细胞基因表达，碱性磷酸酶活性，胶原分泌，抗酒石酸酸性磷酸酶活性和体外骨吸收的影响。

结果显示，Mg在体外和体内抑制破骨细胞分化的早期阶段并抑制骨吸收。然而，Mg在多孔结构中或在植入物周围的周边区域中没有增强体外或体内的成骨作用。对于具有多孔结构的植入物，Mg涂层本身不能改善成骨能力，但可以抑制种植体周围骨溶解，这可能使其有利于骨质疏松症患者。

需要进一步研究以检查Mg诱导的抗骨溶解的精确机制以及Mg涂层植入物对人的长期影响。

原始出处：

Du Z, Yu X, et al., Effects of magnesium coating on bone-implant interfaces with and without polyether-ether-ketone particle interference: A rabbit model based on porous Ti6Al4V implants. J Biomed Mater Res B Appl Biomater. 2019 Jan 26. doi: 10.1002/jbm.b.34332.

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    2019-05-01 huangdf

    #种植#

    0

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    2019-04-02 sunylz

    #Bio#

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    2019-02-03 ms6279672939590805

    #种植体#

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    2019-02-03 ms3994565386320060

    #Med#

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    2019-02-03 smartxiuxiu

    好

    0