BeyondSpring的Plinabulin可防止在化疗期间接受长期输血的癌症患者组织中的铁超载

2020-03-25 MedSci原创 MedSci原创

BeyondSpring公司将在今年的美国国家综合癌症网络(NCCN)年会展现Plinabulin的临床研究数据。Plinabulin在研究中展现出预防接受输血的癌症患者体内铁超载的潜力。

BeyondSpring公司将在今年的美国国家综合癌症网络(NCCN)年会展现Plinabulin的临床研究数据。Plinabulin在研究中展现出预防接受输血的癌症患者体内铁超载的潜力。

化疗通常会引起骨髓抑制,从而导致癌症患者的白细胞和红细胞数量减少(贫血)。在输血过程中,高浓度的游离铁/血红蛋白复合物释放到血液中(称为溶血)结合触珠蛋白,导致触珠蛋白的含量迅速耗尽,使患者无法抵抗铁含量的增加。游离铁水平升高会沉积在患者的组织中,损害心脏、肝脏、内分泌系统和骨髓等重要器官,从而增加发病率和死亡率。

人体中和游离铁/血红蛋白复合物的天然防御机制是触珠蛋白,结合后可以安全地去除铁。将在NCCN上呈现的数据表明,Plinabulin作为一种有效的触珠蛋白诱导剂,可以在输血期间恢复触珠蛋白的含量。在接受化疗的患者中,Plinabulin可剂量依赖性地将触珠蛋白水平提高(p <0.01)至最大水平,使正常触珠蛋白水平增加一倍(p <0.0001)。

该公司首席执行官Mohanlal博士说:"癌症治疗的最新进展,例如免疫疗法与化疗相结合正在将癌症从致命疾病转变为慢性疾病,并且许多患者能够获得较长的寿命。需要经常接受化疗并输血势必会造成癌症患者组织中的铁超载,从而对他们的整体生存产生负面影响。Plinabulin诱导的触珠蛋白可以安全地消除组织中的过量铁,从而改善癌症患者的预后。"

原始出处:

https://www.firstwordpharma.com/node/1710088?tsid=4

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    2020-03-27 windight
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