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JACC：造血细胞的突变会恶化心衰的预后

2018-02-25 MedSci MedSci原创

心血管造血细胞心衰
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近期研究表明，白血病相关基因的体细胞突变可以导致造血干细胞的无性克隆，并且随着年龄的增大，这些突变的淋巴细胞会在血液中积累。这些体细胞突变相关的造血细胞在老年人中更常见，并且与心血管疾病发生的风险相关。本研究的目的旨在评估造血细胞中Tet2基因突变对心衰发生的影响。本研究通过主动脉结扎引起的后负荷诱导小鼠产生心衰，竞争性骨髓移植有Tet2缺陷的细胞来模拟TET2突变的造血细胞，另外，建立特异性在骨

近期研究表明，白血病相关基因的体细胞突变可以导致造血干细胞的无性克隆，并且随着年龄的增大，这些突变的淋巴细胞会在血液中积累。这些体细胞突变相关的造血细胞在老年人中更常见，并且与心血管疾病发生的风险相关。本研究的目的旨在评估造血细胞中Tet2基因突变对心衰发生的影响。

本研究通过主动脉结扎引起的后负荷诱导小鼠产生心衰，竞争性骨髓移植有Tet2缺陷的细胞来模拟TET2突变的造血细胞，另外，建立特异性在骨髓中敲除TET2基因的小鼠模型。结果发现，在两种心衰小鼠模型中，造血系统或者骨髓的TET2的缺陷均能破坏心脏的重塑和心功能，并伴随着IL-1β的表达升高。经过选择性NLRP3炎性体抑制剂的治疗，可以保护小鼠的心衰进展，并消除心功能在TET2缺陷组和正常组间的差异。

研究结果显示，Tet2的缺失会恶化心衰小鼠的心功能，并伴随着IL-1β的表达升高。

原始出处：

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    2018-03-20 ailian1211

    #血细胞#

    0

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    2019-01-19 hbwxf

    #JACC#

    0

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    2018-02-27 12498568m50暂无昵称

    #ACC#

    0

  4. 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likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Feb 25 16:11:23 CST 2018, time=2018-02-25, status=1, ipAttribution=)]
    2018-02-27 俅侠

    #造血#

    0

  5. 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    2018-02-27 lq1774

    #造血细胞#

    0

  6. 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likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Feb 25 16:11:23 CST 2018, time=2018-02-25, status=1, ipAttribution=)]
    2018-02-26 清风拂面

    谢谢分享学习

    0

  7. 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likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Feb 25 16:11:23 CST 2018, time=2018-02-25, status=1, ipAttribution=)]
    2018-02-26 yfjms

    学习

    0

  8. 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likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Feb 25 16:11:23 CST 2018, time=2018-02-25, status=1, ipAttribution=)]
    2018-02-25 爱吃鱼的菜

    学习.谢谢分享!

    0

  9. 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likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Feb 25 16:11:23 CST 2018, time=2018-02-25, status=1, ipAttribution=)]
    2018-02-25 明月清辉

    谢谢分享.学习了

    0

  10. 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likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Feb 25 16:11:23 CST 2018, time=2018-02-25, status=1, ipAttribution=)]
    2018-02-25 1e0f8808m18(暂无匿称)

    好文章.学习了.

    0

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