阜外医院动物试验发现,新型可吸收药物洗脱冠脉支架的短期有效性和安全性较好,内皮覆盖快

2019-08-17 佚名 中国循环杂志

近期,阜外医院邱洪、郑剑峰等人通过开展小型猪冠状动脉模型研究发现,新型可吸收药物洗脱冠状动脉支架(IBS支架)与目前临床广泛应用的Xience Prime支架(钴铬合金依维莫司药物洗脱支架)的短期安全性和有效性相似,前者在置入早期可更迅速且完整地实现内皮覆盖。


近期,阜外医院邱洪、郑剑峰等人通过开展小型猪冠状动脉模型研究发现,新型可吸收药物洗脱冠状动脉支架(IBS支架)与目前临床广泛应用的Xience Prime支架(钴铬合金依维莫司药物洗脱支架)的短期安全性和有效性相似,前者在置入早期可更迅速且完整地实现内皮覆盖。
 
研究者指出,支架的厚度、外形、构型和支撑力是设计的关键因素,而IBS支架厚度比当前主流支架更薄,意味着更灵活的输送和更好的贴壁效果,并且在研究中其良好的性能也得以表现。
 
研究者将28枚IBS支架(IBS组)和28枚Xience Prime支架(Xience Prime组)
随机置入28 头非动脉粥样硬化小型猪的两支主要冠状动脉。支架置入7 天、14 天及28 天后,应用光学相干断层扫描(OCT)、微型计算机断层扫描(Micro-CT)、扫面电镜(SEM)和组织病理学检查评估IBSTM 支架短期的安全性及有效性。
 
结果显示:所有实验动物均未发生不良心血管事件。支架置入28 天后,两组间面积狭窄率、血管损伤积分和炎症积分均无明显差异。IBS组的纤维沉积积分高于Xience Prime组(1.29分 vs 0.6分)。
 
Micro-CT 显示,28 天时,IBS支架并未出现任何腐蚀,仍然保持其结构的完整性。与Xience Prime支架相比,IBS支架在置入7天(77% vs 30%)和14天(87% vs 64%)时有更高的内皮覆盖率,但到28 天时两组间并无显著差异(96% vs 97%)。
 
免疫组化结果页显示,IBS支架组内皮细胞生理功能有所恢复。

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