Biomater Sci:空气等离子体处理促进蛋白质膜上的骨样纳米羟基磷灰石形成,以增强体内成骨

2019-03-26 不详 网络

将羟基磷灰石(HAp)引入生物分子材料是改善其骨再生能力的有前景的方法。因此,需要开发一种简便的方法来实现这一目标。在这里,我们表明,对丝纤蛋白(SF)薄膜进行简单的空气等离子体处理5分钟,诱导其表面形成骨状板状纳米HAp(nHAp),并且所得材料有效地增强了体内成骨。与原始SF膜(称为SF)相比,经空气等离子体处理的SF膜(称为A-SF)呈现出表面纳米柱并增强了亲水性,使得A-SF和SF膜诱导形

将羟基磷灰石(HAp)引入生物分子材料是改善其骨再生能力的有前景的方法。因此,需要开发一种简便的方法来实现这一目标。在这里,我们表明,对丝纤蛋白(SF)薄膜进行简单的空气等离子体处理5分钟,诱导其表面形成骨状板状纳米HAp(nHAp),并且所得材料有效地增强了体内成骨。

与原始SF膜(称为SF)相比,经空气等离子体处理的SF膜(称为A-SF)呈现出表面纳米柱并增强了亲水性,使得A-SF和SF膜诱导形成板状/更多-晶体和针状/较少结晶的nHAp。将矿化的A-SF和SF膜(分别称为A-SF-nHAp和SF-nHAp)和它们的非矿化对应物接种大鼠间充质干细胞并皮下植入大鼠模型中。由于其独特的纳米形貌,A-SF-nHAp和A-SF膜在4周内表现出比SF-nHAp和SF膜更有效的骨形成,其中A-SF-nHAp膜比A-SF膜更有效。

总之,这项工作表明,空气-等离子体处理和随后的nHAp矿化的组合最有效地促进骨形成,一种提高蛋白质生物材料骨再生能力的有吸引力的方法。

原始出处:

Zhang Q, Ma L, et al., Air-plasma treatment promotes bone-like nano-hydroxylapatite formation on protein films for enhanced in vivo osteogenesis. Biomater Sci. 2019 Mar 25. doi: 10.1039/c9bm00020h.

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    2020-01-04 sunylz
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    2019-03-28 zhaojie88
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