Nat Commun:预测美国的季节性流感

2014-01-06 Nature中文网 Nature中文网

本期Nature Communications报告了对美国季节性流感高峰的准确预测。这项工作表明,对流感发生时间的准确预测(提前量最多达到九星期)可以通过利用对病毒发现率的实时观察的一个简单模型来实现。 虽然对温带地区流感发病的一般性冬季高峰期已有很好描述,疫苗接种计划也已实施,但在任何一个给定的年份每次局部爆发的具体发生时间、流行程度和持续时间都是高度可变的。如果这些特点能够得到可靠预测,那么

本期Nature Communications报告了对美国季节性流感高峰的准确预测。这项工作表明,对流感发生时间的准确预测(提前量最多达到九星期)可以通过利用对病毒发现率的实时观察的一个简单模型来实现。【原文下载

虽然对温带地区流感发病的一般性冬季高峰期已有很好描述,疫苗接种计划也已实施,但在任何一个给定的年份每次局部爆发的具体发生时间、流行程度和持续时间都是高度可变的。如果这些特点能够得到可靠预测,那么公共卫生部门的应对措施也许能得到更好的协调。

Jeffrey Shaman及同事报告了在2012-2013流感季节对美国108个城市的季节性流感每周所做的实时预测。他们的系统基于以前用来在纽约市产生追溯预测结果的一个方法,它综合了新感染人数、易感人数、区域高峰和总爆发病例数。通过这种办法,产生了对流感爆发高峰时间的可靠预测,预测的提前量在一些州长达九星期。作者报告,每周预测的准确性在不同城市之间的确有所不同。一些地方,如伯明翰、堪萨斯城和布法罗,在整个流感季节、在当地所观察到的高峰期过去之前和之后都得到了准确预测,而芝加哥和新奥尔良等其他城市的爆发高峰期从未得到很好预测。在包括圣迭戈、亚特兰大和波士顿在内的很多城市,预测的准确性随流感季节的发展不断提高。总体上, 各城市预测准确性随流感季节发展从19%提高到74%;到第52周,流感病毒高峰周的全部集合预测中63%的准确性都在1周之内.

原文出处

Shaman J, Karspeck A, Yang W, Tamerius J, Lipsitch M.Real-time influenza forecasts during the 2012-2013 season.Nat Commun. 2013 Dec 3【原文下载

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    2014-08-07 liuli5079
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