Metab Syndr Relat Disord:糖尿病可使中年人认知功能恶化

2018-12-21 国际糖尿病编辑部 国际糖尿病

一项基于人群的研究发现,与非糖尿病成人相比,患有糖尿病的中年人在执行力、注意力和记忆力方面的表现更差,且独立于其他心血管危险因素和抑郁状态。

一项基于人群的研究发现,与非糖尿病成人相比,患有糖尿病的中年人在执行力、注意力和记忆力方面的表现更差,且独立于其他血管危险因素和抑郁状态。

美国迈阿密大学Leonardo Tamariz及其同事指出,研究显示改善血糖控制可降低糖尿病对认知功能的影响,但相关数据大多来自老年人,有关中年患者的信息非常有限。

在一项横断面研究中,Tamariz及其同事对从厄瓜多尔瓜亚基尔市入选的309例年龄55~65岁有糖尿病(n=142,平均病程10.15年)和无糖尿病(n=167)的成人数据进行了分析。受试者完成了包含9个语言和非语言任务的标准化神经心理测试。研究者还收集抑郁症、教育程度、吸烟和饮酒情况相关数据,并使用方差分析评估糖尿病和非糖尿病患者之间的差异。

与非糖尿病受试者相比,糖尿病患者更多为女性(54.2% vs. 30.5%)、受教育程度更低(平均11.82年vs. 13.32年;P<0.05)、平均腰围更大(98.31 cm vs. 93.57 cm;P<0.01)。然而,与糖尿病患者相比,非糖尿病受试者的总胆固醇、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇水平均较高(P<0.01)。

研究者发现,与非糖尿病受试者相比,糖尿病患者在记忆力、注意力、信息处理和执行力等所有评估指标上的表现明显更差。在记忆任务中,糖尿病患者在即时和延迟记忆条件下记住的单词和复杂图形细节更少。在注意力和信息处理速度测试中,他们比对照组能够重复的数字、读出的单词和认出的颜色均更少。此外,糖尿病患者需要更多时间来完成简单的数字排列以及在选择反应时间任务中做出“是”或“否”的选择。在试验B部分,糖尿病患者完成任务时间更长,且犯错更多(P=0.002)。

在多变量分析中,糖尿病状态是大多数记忆任务表现的预测因素,在校正了教育程度、高血压和抑郁症状后,结果仍存在。研究者指出,在患有糖尿病的中年人中普遍存在轻度认知障碍。因此,需采取筛查措施来识别这些患者。

原始出处:
Michael Palacios-Mendoza, et al. Diabetes Is Associated with Cognitive Decline in Middle-Aged Patients. Metabolic Syndrome and Related Disorders. Nov 2018.

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    2019-07-02 guojianrong
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    2019-06-22 cmsvly
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    2019-10-29 一闲
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  6. [GetPortalCommentsPageByObjectIdResponse(id=1887971, encodeId=c97a188e9713c, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Tue Jul 02 17:39:00 CST 2019, time=2019-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784409, encodeId=b62a1e844092f, content=<a href='/topic/show?id=a727600194' target=_blank style='color:#2F92EE;'>#Disord#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6001, encryptionId=a727600194, topicName=Disord)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aad0444, createdName=cmsvly, createdTime=Sat Jun 22 11:39:00 CST 2019, time=2019-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1896436, encodeId=9a42189643659, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Tue Oct 29 09:39:00 CST 2019, time=2019-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2012882, encodeId=12cd201288212, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Thu Jan 03 13:39:00 CST 2019, time=2019-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574909, encodeId=6d0015e4909f8, content=<a href='/topic/show?id=4f432212e79' target=_blank style='color:#2F92EE;'>#中年人#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22127, encryptionId=4f432212e79, topicName=中年人)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ffb16038617, createdName=yhj-time, createdTime=Sun Dec 23 13:39:00 CST 2018, time=2018-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356072, encodeId=60143560e206, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Sat Dec 22 07:51:45 CST 2018, time=2018-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042129, encodeId=c9b2104212923, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sat Dec 22 01:39:00 CST 2018, time=2018-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356054, encodeId=390135605437, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sat Dec 22 01:16:04 CST 2018, time=2018-12-22, status=1, ipAttribution=)]
    2018-12-22 深海的鱼

    学习学习学习

    0

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    2018-12-22 misszhang

    谢谢MedSci提供最新的资讯

    0

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    2018-12-22 飛歌

    学习了很有用不错

    0

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