J Am Geriatr Soc:老年糖尿病患者增加抑郁症发生的风险

2016-05-30 phylis 译 MedSci原创

目的:在基于人群的队列中,确定糖尿病是否增加中老年人抑郁症状。设计:前瞻性队列研究。参与者:受试者是来自1998-99年萨克拉门托拉丁美洲老化研究,受试者年龄60岁或以上的老年人,随访至2008(n = 1586)。测量:根据自我报告确定糖尿病,空腹血糖为126毫克/升或更高,糖化血红蛋白为6.5%或更高,或使用糖尿病药物。抑郁症状定义为流行病学研究中心抑郁量表(CES-D)评分16或更高,或使用

目的:在基于人群的队列中,确定糖尿病是否增加中老年人抑郁症状。

设计:前瞻性队列研究。

参与者:受试者是来自1998-99年萨克拉门托拉丁美洲老化研究,受试者年龄60岁或以上的老年人,随访至2008(n = 1586)。

测量:根据自我报告确定糖尿病,空腹血糖为126毫克/升或更高,糖化血红蛋白为6.5%或更高,或使用糖尿病药物。抑郁症状定义为流行病学研究中心抑郁量表(CES-D)评分16或更高,或使用抗抑郁药物。应用Multistate Markov模型评估糖尿病的时间依赖性对三种状态转换的影响:低CES-D得分(正常),高CES-D得分或治疗(抑郁)和死亡。双变量分析确定的任何过渡显著相关的协变量,包括性别和年龄、教育、BMI、高血压、中风等基线参数。

结果:在充分校正模型中,糖尿病的受试者发展成为抑郁症状,或者开始抗抑郁药物治疗率高达35%(HR= 1.35,95% CI= 1.13-1.62)。时间依赖的糖尿病率与从抑郁转向正常率相关(HR = 0.72,95% CI = 0.59-0.88),并且从抑郁进展到死亡率为2.3(HR = 2.31,95% CI = 1.57-3.40)。

结论:糖尿病增加老年墨西哥美国人抑郁症状的风险。老年糖尿病患者应筛查抑郁症状和优先进行密切随访。

原始出处:

Garcia ME, Lee A, et al. Diabetes Mellitus as a Risk Factor for Development of Depressive Symptoms in a Population-Based Cohort of Older Mexican Americans. J Am Geriatr Soc. 2016 Mar.


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  2. [GetPortalCommentsPageByObjectIdResponse(id=2021527, encodeId=8bd0202152e9a, content=<a href='/topic/show?id=31e8e9669d' target=_blank style='color:#2F92EE;'>#GER#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7966, encryptionId=31e8e9669d, topicName=GER)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=48732500158, createdName=12498c32m68暂无昵称, createdTime=Mon Feb 06 05:21:00 CST 2017, time=2017-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129110, encodeId=e3b912911000, content=赞一个!好文章拜读了,认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Sep 17 08:24:00 CST 2016, time=2016-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=127542, encodeId=b88512e54242, content=关注身体健康,也要关注心理健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Thu Sep 15 14:27:00 CST 2016, time=2016-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88125, encodeId=80a7881256d, content=好文章,得多学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=53751677671, createdName=沉心多思, createdTime=Thu Jun 02 02:35:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473985, encodeId=89d314e3985c5, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Wed Jun 01 13:21:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479521, encodeId=ed5314e95216f, content=<a href='/topic/show?id=466b8021e01' target=_blank style='color:#2F92EE;'>#老年糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80217, encryptionId=466b8021e01, topicName=老年糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5bf97540688, createdName=ms3323097325231039, createdTime=Wed Jun 01 13:21:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87899, encodeId=11278e89978, content=抑郁症患者太痛苦, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn//images/medsci_toux.jpg, createdBy=7af91730839, createdName=足球疯子, createdTime=Tue May 31 21:03:00 CST 2016, time=2016-05-31, status=1, ipAttribution=)]
    2016-09-17 ylzr123

    赞一个!好文章拜读了,认真学习了。

    0

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    2016-09-15 舒心和人

    关注身体健康,也要关注心理健康

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2021527, encodeId=8bd0202152e9a, content=<a href='/topic/show?id=31e8e9669d' target=_blank style='color:#2F92EE;'>#GER#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7966, encryptionId=31e8e9669d, topicName=GER)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=48732500158, createdName=12498c32m68暂无昵称, createdTime=Mon Feb 06 05:21:00 CST 2017, time=2017-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129110, encodeId=e3b912911000, content=赞一个!好文章拜读了,认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Sep 17 08:24:00 CST 2016, time=2016-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=127542, encodeId=b88512e54242, content=关注身体健康,也要关注心理健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Thu Sep 15 14:27:00 CST 2016, time=2016-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88125, encodeId=80a7881256d, content=好文章,得多学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=53751677671, createdName=沉心多思, createdTime=Thu Jun 02 02:35:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473985, encodeId=89d314e3985c5, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Wed Jun 01 13:21:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479521, encodeId=ed5314e95216f, content=<a href='/topic/show?id=466b8021e01' target=_blank style='color:#2F92EE;'>#老年糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80217, encryptionId=466b8021e01, topicName=老年糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5bf97540688, createdName=ms3323097325231039, createdTime=Wed Jun 01 13:21:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87899, encodeId=11278e89978, content=抑郁症患者太痛苦, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn//images/medsci_toux.jpg, createdBy=7af91730839, createdName=足球疯子, createdTime=Tue May 31 21:03:00 CST 2016, time=2016-05-31, status=1, ipAttribution=)]
    2016-06-02 沉心多思

    好文章,得多学习了!

    0

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    2016-05-31 足球疯子

    抑郁症患者太痛苦

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