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Clin Proteomics：异常循环微粒清除缺陷或促进了系统性红斑狼疮的发生

2017-08-08 MedSci MedSci原创

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目前对系统性红斑狼疮（SLE）的发病机制了解甚少，但与亚循环中亚细胞颗粒物质的清除缺陷有关。本研究以系统性硬化症患者（SSc）和健康供体（HC）作为对照的综合MP蛋白质分析为基础，研究SLE患者循环微粒（MPs）的起源，形成和特异性。研究人员将SLE（n = 45），SSc（n = 38）和HC（n = 35，n = 25）组样品进行差速离心，从去血小板血浆中纯化MPs。在经胰蛋白酶消化后通过液相

目前对系统性红斑狼疮（SLE）的发病机制了解甚少，但与亚循环中亚细胞颗粒物质的清除缺陷有关。本研究以系统性硬化症患者（SSc）和健康供体（HC）作为对照的综合MP蛋白质分析为基础，研究SLE患者循环微粒（MPs）的起源，形成和特异性。 研究人员将SLE（n = 45），SSc（n = 38）和HC（n = 35，n = 25）组样品进行差速离心，从去血小板血浆中纯化MPs。在经胰蛋白酶消化后通过液相色谱-串联质谱法鉴定和定量MP蛋白。使用单变量统计学和多次比较的错误发现率校正来比较组间特异性蛋白质的丰度。通过受体操作特征曲线和蛋白质丰度与疾病活动评分的相关性分析，探索诊断和疾病活动信息的特异性蛋白质和蛋白质比例。 结果，研究人员识别并定量了1000多种 MP蛋白，并显示SLE-MPs（建议称为luposomes）的亚群对于SLE是高度特异性的，即在HC或具有另一自身免疫性系统性性疾病，SSc的患者的MP样本中未发现。在SLE-MPs中，血小板蛋白和线粒体蛋白显着减少，细胞骨架蛋白紊乱，糖酵解酶和凋亡蛋白显着增加。 总之，该研究表明，正常MPs在SLE中被有效清除，但来自非淋巴细胞

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    2017-11-16 sunylz

    #Proteomics#

    0

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    2018-02-12 qingrejiedu

    #系统性#

    0

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    2017-08-10 sunrural_42825357

    #狼疮#

    0

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    2017-08-10 zhouqu_8

    #红斑#

    0

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    2017-08-10 sunylz

    #PRO#

    0