Eur Urol:精索静脉曲张会导致健康男性精液质量降低

2016-08-01 MedSci MedSci原创

研究人员指出,精索静脉曲张会导致健康男性的精液质量降低,并改变男性雄激素水平。欧洲泌尿协会指出,约15%的成年男性会出现精索静脉曲张,导致男性出现原发性不孕(35-44%)或继发性不孕症(45-81%)的风险增加。 丹麦哥本哈根大学的Niels Joergensen博士和同事们对7000多名欧洲青年进行精索静脉曲张、睾丸功能测试、精液和机体雄激素水平分析等数据进行了探究。他们指出,超过六分之一的男

研究人员指出,精索静脉曲张会导致健康男性的精液质量降低,并改变男性雄激素水平。欧洲泌尿协会指出,约15%的成年男性会出现精索静脉曲张,导致男性出现原发性不孕(35-44%)或继发性不孕症(45-81%)的风险增加。 

丹麦哥本哈根大学的Niels Joergensen博士和同事们对7000多名欧洲青年进行精索静脉曲张、睾丸功能测试、精液和机体雄激素水平分析等数据进行了探究。他们指出,超过六分之一的男性(15.7%)被诊断出患有精索静脉曲张。

精索静脉曲张男性分泌的精液量减少,超过一半的精索静脉曲张男性参与则精液中精子质量降低,仅有17%的精索静脉曲张的男性参与者精液中精子质量较高。随着精索静脉曲张程度的加重,男性精液中精子浓度也随之降低。精索静脉曲张程度为3级的男性精子浓度低于无精索静脉曲张男性的一半(2300万/mL:5000万/mL),精子数量也同样如此。3级精索静脉曲张的男性精液中正常形态的精子数量所占比重为5.1%,无精索静脉曲张的男性精液中正常形态的精子数量所占比重为7.2%。

相比无精索静脉曲张男性而言,精索静脉曲张男性血FSH和LH水平明显增加,但抑制素B水平降低。二者血睾酮、游离睾酮水平无明显差异。这项大型横断面临床研究表明,精索静脉曲张男性的精液质量明显降低。 

奥尔巴尼医学院的Andrew McCullough博士指出,临床医生必须重视起来,精索静脉曲张较早出现于青春期,只需5-6年便可对男孩造成今后的伤害。许多年龄在35岁以上的中年男性因不孕就诊时被诊断出患有精索静脉曲张,此时他们出现精索静脉曲张的时间应该有20-30年了,且出现睾丸萎缩和激素水平异常的风险增加。因此研究人员建议儿科医生为青春期少年进行一次全面体检,一旦发现少年出现精索静脉曲张应立即就诊。

原始出处:

[1] Impaired Semen Quality Altered Hormone Levels With Varicocele,Medscape,29,Jul,2016

[2] Jakob Damsgaarda,et al. Varicocele Is Associated with Impaired Semen Quality and Reproductive Hormone Levels: A Study of 7035 Healthy Young Men from Six European Countries. Eur Urol.2016 July 29.

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    2016-10-29 fusion
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    2016-09-24 功腾新医

    好文章,多看看,年轻医生要不断进步

    0

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    2016-09-12 1e10c84am36(暂无匿称)

    文章不错

    0

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    2016-08-03 hb2008ye

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