Clin Gastroenterol H:急性非静脉曲张性上消化道出血的高危患者急诊内镜的结局和作用!

2017-06-18 xing.T MedSci原创

由此可见,急诊内镜检查是降低死亡率的独立预测因子,但在高危急性非静脉曲张性UGIB患者中与再出血不相关。

近日,消化病领域权威杂志Clinical Gastroenterology and Hepatology发表了一篇研究文章,研究人员旨在评估急性非静脉曲张性上消化道出血(UGIB)高风险患者的临床结局,并确定急诊内镜检查是否有效。

研究人员纳入了于2005年1月1日至2014年12月31日期间在急诊因急性非静脉曲张性UGIB而接受内镜检查的且格拉斯哥-Blatchford评分>7的患者。紧急(<6h)和择期(6-48 h)内镜被根据初诊到内镜检查的时间来定义。该研究的主要转归为入院28天内的死亡率和再出血率。

在961例患者中,571例接受了急诊内镜检查。28天死亡率为2.5%,再出血率为10.4%。研究人员分析在死亡率(1.6% vs. 3.8%)、输注红细胞悬液(2.6±2.5 vs. 2.3±2.1包)、需要干预(69.5% vs. 53.5%)、栓塞(2.8% vs. 0.5%)上存在显著差异,但在再出血、入住ICU、升压药的使用和住院长短方面接受急诊和择期内镜检查的患者没有差异。死亡率与恶性肿瘤(比值比[OR]为3.58,95%可信区间[CI]为1.33-9.62)、肝硬化(OR为4.67,95%CI为1.85-11.76)、急诊内镜检查(OR为0.36,95%CI为0.14-0.95),失败的主要内镜治疗(OR为15.03,95%CI为4.63-48.82)和再出血(OR为2.77,95%CI为1.03-7.45)相关。再出血和Forrest I溃疡(OR为7.67,95%CI为2.71-21.69),Forrest II溃疡(OR为2.34,95%CI为1.51-3.60)和凝血功能障碍(OR为2.34,95%CI为1.51-3.60)相关。

由此可见,急诊内镜检查是降低死亡率的独立预测因子,但在高危急性非静脉曲张性UGIB患者中与再出血不相关。

原始出处:


Soo-Han Cho,et al. Outcomes and role of urgent endoscopy in high-risk patients with acute nonvariceal gastrointestinal bleeding. Clinical gastroenterology and hepatology 2017. http://www.cghjournal.org/article/S1542-3565(17)30736-X/fulltext

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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464535, encodeId=8a3814645353f, content=<a href='/topic/show?id=32e765e6591' target=_blank style='color:#2F92EE;'>#消化道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65765, encryptionId=32e765e6591, topicName=消化道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7b6e6676048, createdName=changhe715, createdTime=Tue Jun 20 04:38:00 CST 2017, time=2017-06-20, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1711083, encodeId=a0b21e110839c, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Tue Feb 13 17:38:00 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697480, encodeId=5f27169e480cd, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, 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encodeId=eaa5215423b0, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Mon Jun 26 06:21:25 CST 2017, time=2017-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1261916, encodeId=e85d1261916e0, content=<a href='/topic/show?id=0ceb30545e0' target=_blank style='color:#2F92EE;'>#内镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30545, encryptionId=0ceb30545e0, topicName=内镜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Tue Jun 20 04:38:00 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464535, encodeId=8a3814645353f, content=<a href='/topic/show?id=32e765e6591' target=_blank style='color:#2F92EE;'>#消化道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65765, encryptionId=32e765e6591, topicName=消化道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7b6e6676048, createdName=changhe715, createdTime=Tue Jun 20 04:38:00 CST 2017, time=2017-06-20, status=1, ipAttribution=)]
    2017-11-21 许安
  6. [GetPortalCommentsPageByObjectIdResponse(id=1711083, encodeId=a0b21e110839c, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Tue Feb 13 17:38:00 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697480, encodeId=5f27169e480cd, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, 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  7. 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  8. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464535, encodeId=8a3814645353f, content=<a href='/topic/show?id=32e765e6591' target=_blank style='color:#2F92EE;'>#消化道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65765, encryptionId=32e765e6591, topicName=消化道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7b6e6676048, createdName=changhe715, createdTime=Tue Jun 20 04:38:00 CST 2017, time=2017-06-20, status=1, ipAttribution=)]
    2017-06-26 大爰

    学习了谢谢分享!!

    0

  9. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464535, encodeId=8a3814645353f, content=<a href='/topic/show?id=32e765e6591' target=_blank style='color:#2F92EE;'>#消化道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65765, encryptionId=32e765e6591, topicName=消化道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7b6e6676048, createdName=changhe715, createdTime=Tue Jun 20 04:38:00 CST 2017, time=2017-06-20, status=1, ipAttribution=)]
    2017-06-20 docwu2019
  10. 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