Int J Cardiol:外周动脉疾病男性患者血运重建率较低和预后不良!

2017-12-29 xing.T MedSci原创

该研究的数据显示特别是在晚期PAD(CLI)患者中血运重建率较低。男性患者更多地通过外科手术进行血管再通,但较少使用血管内治疗,并且随访期间截肢率和死亡率较高。

很少有数据讨论性别对周围动脉疾病(PAD)患者诊断、治疗程序和结局的影响。近日,心血管领域权威杂志International Journal of Cardiology上发表了一篇研究文章,研究人员从德国最大的公共健康保险(BARMER GEK)获得了41873例PAD患者2009年至2011年之间的数据(包括4年的随访)。倾向评分匹配(PSM)评估性别对治疗、并发症、住院和长期预后的影响。

在41873例PAD患者中,男性有23282例(55.6%),女性有18591例(44.4%)。男性参与者年龄较小(69±11岁 vs. 女性75±12岁,P<0.001),但肥胖(8% vs. 6.5%)、血脂异常(33.2% vs. 28.1%)、吸烟(12.9% vs. 9.2%)、冠心病(29.4% vs. 19.5%)和糖尿病(35.8% vs. 28.1%,P<0.001)的发生率较高。

几乎五分之三的血管成形术运用于临床早期,重要肢体缺血(CLI)的血管再通率在男性和女性中住院时为49%,在随访期间为58.8%。考虑了危险因素和PAD分期的PSM显示相比于女性,男性较少地使用血管内治疗,而是更多地使用手术血管重建术。男性患者住院截肢率较高,并且是随访期间截肢(风险比为1.284,P<0.001)和死亡(风险比为1.155,P<0.001)的独立危险因素。

该研究的数据显示特别是在晚期PAD(CLI)患者中血运重建率较低。男性患者更多地通过外科手术进行血管再通,但较少使用血管内治疗,并且随访期间截肢率和死亡率较高。

原始出处:


Eva Freisinger et al. Low rate of revascularization procedures and poor prognosis particularly in male patients with peripheral artery disease — A propensity score matched analysis.International Journal of Cardiology.2017. https://doi.org/10.1016/j.ijcard.2017.12.054

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    2018-01-09 大爰

    学习了谢谢分享!!

    0

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    2018-01-02 大爰

    学习并分享!!

    0

  5. 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GetPortalCommentsPageByObjectIdResponse(id=273442, encodeId=56b52e344232, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Fri Dec 29 07:47:46 CST 2017, time=2017-12-29, status=1, ipAttribution=)]
    2017-12-30 sunfeifeiyang

    学习

    0

  8. 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GetPortalCommentsPageByObjectIdResponse(id=273442, encodeId=56b52e344232, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Fri Dec 29 07:47:46 CST 2017, time=2017-12-29, status=1, ipAttribution=)]
    2017-12-29 天涯183

    非常好的文章.学习了

    0

  9. 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GetPortalCommentsPageByObjectIdResponse(id=273442, encodeId=56b52e344232, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Fri Dec 29 07:47:46 CST 2017, time=2017-12-29, status=1, ipAttribution=)]
    2017-12-29 龙胆草

    学习谢谢分享

    0

  10. 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GetPortalCommentsPageByObjectIdResponse(id=273442, encodeId=56b52e344232, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Fri Dec 29 07:47:46 CST 2017, time=2017-12-29, status=1, ipAttribution=)]
    2017-12-29 Y—xianghai

    学习了新知识

    0

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ARISTOTLE研究中的PAD患者相比于没有PAD患者存在更高的未经调整的脑卒中或全身栓塞的风险,而调整后就不复存在。阿哌沙班与华法林治疗对脑卒中和全身性栓塞的益处在PAD患者和不是PAD患者中是相似的。这些发现强调需要优化房颤和PAD患者的治疗。

ATVB:更多地摄入水果和蔬菜与较低的外周动脉疾病患病率相关!

该研究的结果表明F&V消耗量与PAD患病之间呈负相关性,而且整体F&V消耗量较低。这些观察结果表明需要进一步努力以提高F&V的消耗量,并且更严格地评估F&V在预防PAD中的作用。

Theranostics:干细胞治疗有望改善糖尿病人的外周动脉病变

外周动脉病变(PAD)在糖尿病人中非常常见。在PAD中,四肢的动脉变窄,由于缺乏血液和氧气,会引起四肢疼痛和活动受限。PAD的治疗选择很少,许多患者需要接受手术来放置血管支架或动脉旁路。如果PAD不治疗,往往会导致足部溃疡和截肢,在美国每年有数***因此截肢,造成巨大的医疗成本和患者生活质量下降。

Circ-Cardiovasc Inte:血小板反应性与临床预后有啥关系?

PAD病史与成功的冠状动脉药物洗脱支架植入术后2年缺血性和出血性结局相关,然而,这些相关性并没有直接被血小板反应性增加所介导。

JAHA:门诊和住院病人外周动脉疾病患病率和发病率估计!

本研究对门诊和住院患者PAD的发生提供了全面的估计,并发现了大部分的PAD负担。PAD是一种重要的循环系统疾病,其患病率类似于卒中和冠心病。