帕金森病前驱期诊断研究标准中国专家共识

2019-08-30 中华医学会神经病学分会帕金森病及运动障碍学组 中华老年医学杂志.2019.38(8):825-831.

帕金森病是老年人常见的神经系统退行性疾病,其典型病理改变为α一突触核蛋白聚集分布于全身多个器官和多巴胺能神经元缺失,从而导致运动和非运动症状。从患者出现第一个帕金森病非运动症状到符合临床诊断标准之间的前驱期阶段可长达20年。帕金森病病程发展不可逆,而目前所有药物和手术治疗均只能改善患者的临床症状,无法治愈疾病。已开展的针对发病患者的神经保护药物临床试验尚未获得确切的阳性结果,可能的原因之一是干预治

中文标题:

帕金森病前驱期诊断研究标准中国专家共识

发布日期:

2019-08-30

简要介绍:

帕金森病是老年人常见的神经系统退行性疾病,其典型病理改变为α一突触核蛋白聚集分布于全身多个器官和多巴胺能神经元缺失,从而导致运动和非运动症状。从患者出现第一个帕金森病非运动症状到符合临床诊断标准之间的前驱期阶段可长达20年。帕金森病病程发展不可逆,而目前所有药物和手术治疗均只能改善患者的临床症状,无法治愈疾病。已开展的针对发病患者的神经保护药物临床试验尚未获得确切的阳性结果,可能的原因之一是干预治疗的时间太晚,已错过疾病的代偿期。我国人群帕金森病相关基因的构成和危险程度与欧美人群存在较大差异;环境因素的暴露和生活习惯与欧美人群不同,因此有必要结合中国人相关研究数据制定适合中国人的帕金森病前驱期诊断研究标准,以便指导我国对帕金森病前驱期的相关研究。

 

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    2022-04-07 飞行的小土豆

    学习

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    2021-04-29 zhanggejuan

    感谢分享

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    2021-03-07 CC031900

    学习良多

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