排卵障碍性异常子宫出血诊治指南

2018-12-25 中华医学会妇产科学分会 中华妇产科杂志.2018, 53(12):801-807.

异常子宫出血(abnormal uterine bleeding,AUB)是妇科临床常见的症状,指不符合正常月经周期“四要素”(即月经的频率、规律性、经期长度和出血量)的正常参数范围、并源自子宫腔的出血。 本指南参照国际妇产科联盟(FIGO)和国内的指南,将AUB限定于生育期非妊娠妇女, 因此排除了妊娠和产褥相关的出血,也不包含青春期前和绝经后出血。FIGO建议弃用术语 “功能失调性子宫出血”,推

中文标题:

排卵障碍性异常子宫出血诊治指南

发布日期:

2018-12-25

简要介绍:

异常子宫出血(abnormal uterine bleeding,AUB)是妇科临床常见的症状,指不符合正常月经周期“四要素”(即月经的频率、规律性、经期长度和出血量)的正常参数范围、并源自子宫腔的出血。 本指南参照国际妇产科联盟(FIGO)和国内的指南,将AUB限定于生育期非妊娠妇女, 因此排除了妊娠和产褥相关的出血,也不包含青春期前和绝经后出血。FIGO建议弃用术语 “功能失调性子宫出血”,推荐使用“急性AUB”替代“大出血”的概念,并将AUB的常见病因分为两大类9个亚型,为方便记忆,按英语首字母缩写为“PALM-COEIN”,即:P表示子宫内膜息肉(polyp)所致AUB、A表示子宫腺肌病(adenomyosis)所致AUB、L表示子宫肌瘤(leiomyoma)所致AUB、M表示子宫内膜恶变和不典型增生(malignancy and hyperplasia)所致AUB、C表示全身凝血相关疾病(coagulopathy)所致AUB(简称: AUB-C)、O表示排卵障碍性(ovulatory dysfunction)AUB(简称:AUB-O)、E表示子宫内膜局部异常(endometrial)所致AUB(简称:AUB-E)、I表示医源性(iatrogenic)AUB (简称:AUB-I)、N表示未分类(not yet lassified) 的AUB(简称:AUB-N)。其中AUB-O最为常见,约占AUB的50%。 排卵障碍包括无排卵、 稀发排卵和黄体功能不足。无排卵主要由下丘脑-垂体-卵巢轴(HPO轴)功能异常引起,常见于青春期、绝经过渡期,生育期也可因多囊卵巢综合征(PCOS)、肥胖、 高催乳素血症、甲状腺和肾上腺疾病等引起;无排卵可以是持续的,也可以是间断或暂时的。无排卵时卵巢无黄体形成和孕激素分泌,引起子宫内膜增殖过度和不规则剥脱而导致AUB,常表现为不规律的月经,频率、规律性、经期长度和出血量均可异常。稀发排卵如不超过60d,可以随访观察,但更长时间的稀发排卵的处理与无排卵相似。黄体功能不足可表现为经间期出血(inter-menstrual bleeding,IMB)。大多数AUB-O能通过药物取得良好的治疗效果。

拓展指南:子宫相关指南:

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  1. [GetPortalCommentsPageByObjectIdResponse(id=978931, encodeId=e3279e8931a6, content=很棒的指南, beContent=null, objectType=guider, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210702/890808c8a034418db259ef05b441d945/562f97bd59d44e77bb224b59d81d4389.jpg, createdBy=06c05539476, createdName=greener, createdTime=Fri Jul 02 10:40:08 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=978929, encodeId=8c809e892976, content=🐮🐮🐮, beContent=null, objectType=guider, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210702/890808c8a034418db259ef05b441d945/562f97bd59d44e77bb224b59d81d4389.jpg, createdBy=06c05539476, createdName=ms5000001768470833, createdTime=Fri Jul 02 10:36:48 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963109, encodeId=148f96310904, content=学习了, beContent=null, objectType=guider, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68772596467, createdName=2419183338, createdTime=Thu May 06 15:14:58 CST 2021, time=2021-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954454, encodeId=241995445436, content=受益匪浅!好文章。, beContent=null, objectType=guider, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Wed Apr 07 13:01:00 CST 2021, time=2021-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954573, encodeId=59b39545e336, content=资料好好,但无法分享,遗憾!, beContent=null, objectType=guider, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1bc65476534, createdName=ms6000001015893838, createdTime=Wed Apr 07 13:46:02 CST 2021, time=2021-04-07, status=1, ipAttribution=)]
    2021-07-02 greener

    很棒的指南

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=978931, encodeId=e3279e8931a6, content=很棒的指南, beContent=null, objectType=guider, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210702/890808c8a034418db259ef05b441d945/562f97bd59d44e77bb224b59d81d4389.jpg, createdBy=06c05539476, createdName=greener, createdTime=Fri Jul 02 10:40:08 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=978929, encodeId=8c809e892976, content=🐮🐮🐮, beContent=null, objectType=guider, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210702/890808c8a034418db259ef05b441d945/562f97bd59d44e77bb224b59d81d4389.jpg, createdBy=06c05539476, createdName=ms5000001768470833, createdTime=Fri Jul 02 10:36:48 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963109, encodeId=148f96310904, content=学习了, beContent=null, objectType=guider, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68772596467, createdName=2419183338, createdTime=Thu May 06 15:14:58 CST 2021, time=2021-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954454, encodeId=241995445436, content=受益匪浅!好文章。, beContent=null, objectType=guider, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Wed Apr 07 13:01:00 CST 2021, time=2021-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954573, encodeId=59b39545e336, content=资料好好,但无法分享,遗憾!, beContent=null, objectType=guider, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1bc65476534, createdName=ms6000001015893838, createdTime=Wed Apr 07 13:46:02 CST 2021, time=2021-04-07, status=1, ipAttribution=)]
    2021-07-02 ms5000001768470833

    🐮🐮🐮

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=978931, encodeId=e3279e8931a6, content=很棒的指南, beContent=null, objectType=guider, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210702/890808c8a034418db259ef05b441d945/562f97bd59d44e77bb224b59d81d4389.jpg, createdBy=06c05539476, createdName=greener, createdTime=Fri Jul 02 10:40:08 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=978929, encodeId=8c809e892976, content=🐮🐮🐮, beContent=null, objectType=guider, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210702/890808c8a034418db259ef05b441d945/562f97bd59d44e77bb224b59d81d4389.jpg, createdBy=06c05539476, createdName=ms5000001768470833, createdTime=Fri Jul 02 10:36:48 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963109, encodeId=148f96310904, content=学习了, beContent=null, objectType=guider, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68772596467, createdName=2419183338, createdTime=Thu May 06 15:14:58 CST 2021, time=2021-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954454, encodeId=241995445436, content=受益匪浅!好文章。, beContent=null, objectType=guider, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Wed Apr 07 13:01:00 CST 2021, time=2021-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954573, encodeId=59b39545e336, content=资料好好,但无法分享,遗憾!, beContent=null, objectType=guider, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1bc65476534, createdName=ms6000001015893838, createdTime=Wed Apr 07 13:46:02 CST 2021, time=2021-04-07, status=1, ipAttribution=)]
    2021-05-06 2419183338

    学习了

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=978931, encodeId=e3279e8931a6, content=很棒的指南, beContent=null, objectType=guider, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210702/890808c8a034418db259ef05b441d945/562f97bd59d44e77bb224b59d81d4389.jpg, createdBy=06c05539476, createdName=greener, createdTime=Fri Jul 02 10:40:08 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=978929, encodeId=8c809e892976, content=🐮🐮🐮, beContent=null, objectType=guider, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210702/890808c8a034418db259ef05b441d945/562f97bd59d44e77bb224b59d81d4389.jpg, createdBy=06c05539476, createdName=ms5000001768470833, createdTime=Fri Jul 02 10:36:48 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963109, encodeId=148f96310904, content=学习了, beContent=null, objectType=guider, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68772596467, createdName=2419183338, createdTime=Thu May 06 15:14:58 CST 2021, time=2021-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954454, encodeId=241995445436, content=受益匪浅!好文章。, beContent=null, objectType=guider, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Wed Apr 07 13:01:00 CST 2021, time=2021-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954573, encodeId=59b39545e336, content=资料好好,但无法分享,遗憾!, beContent=null, objectType=guider, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1bc65476534, createdName=ms6000001015893838, createdTime=Wed Apr 07 13:46:02 CST 2021, time=2021-04-07, status=1, ipAttribution=)]
    2021-04-07 湘雅科教

    受益匪浅!好文章。

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=978931, encodeId=e3279e8931a6, content=很棒的指南, beContent=null, objectType=guider, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210702/890808c8a034418db259ef05b441d945/562f97bd59d44e77bb224b59d81d4389.jpg, createdBy=06c05539476, createdName=greener, createdTime=Fri Jul 02 10:40:08 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=978929, encodeId=8c809e892976, content=🐮🐮🐮, beContent=null, objectType=guider, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210702/890808c8a034418db259ef05b441d945/562f97bd59d44e77bb224b59d81d4389.jpg, createdBy=06c05539476, createdName=ms5000001768470833, createdTime=Fri Jul 02 10:36:48 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963109, encodeId=148f96310904, content=学习了, beContent=null, objectType=guider, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68772596467, createdName=2419183338, createdTime=Thu May 06 15:14:58 CST 2021, time=2021-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954454, encodeId=241995445436, content=受益匪浅!好文章。, beContent=null, objectType=guider, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Wed Apr 07 13:01:00 CST 2021, time=2021-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954573, encodeId=59b39545e336, content=资料好好,但无法分享,遗憾!, beContent=null, objectType=guider, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1bc65476534, createdName=ms6000001015893838, createdTime=Wed Apr 07 13:46:02 CST 2021, time=2021-04-07, status=1, ipAttribution=)]
    2021-04-07 ms6000001015893838

    资料好好,但无法分享,遗憾!

    0