丙型肝炎直接抗病毒药物应用中的药物相互作用管理专家共识

2018-09-08 中华医学会肝病学分会 临床肝胆病杂志.2018.34(9):1855-1861.

DDI 是指两种或两种以上药物同时或在一定时间内先后使用时,在机体因素(药物代谢酶、药物转运蛋白、药物结合蛋白、药物基因多态性等)的参与下,药物因彼此之间交互作用而发生的药动学或(和)药效学的变化,临床表现为药效学增加和(或)不良反应加重,也可表现为药效减弱和(或)不良反应减轻。发生相互作用的两种或多种药物可以不同时共存于机体内,若一种药物对代谢酶或转运蛋白的抑制作用较持久,即使停用此种药物后,机

中文标题:

丙型肝炎直接抗病毒药物应用中的药物相互作用管理专家共识

发布日期:

2018-09-08

简要介绍:

DDI 是指两种或两种以上药物同时或在一定时间内先后使用时,在机体因素(药物代谢酶、药物转运蛋白、药物结合蛋白、药物基因多态性等)的参与下,药物因彼此之间交互作用而发生的药动学或(和)药效学的变化,临床表现为药效学增加和(或)不良反应加重,也可表现为药效减弱和(或)不良反应减轻。发生相互作用的两种或多种药物可以不同时共存于机体内,若一种药物对代谢酶或转运蛋白的抑制作用较持久,即使停用此种药物后,机体恢复该酶活性仍需要一定时间。如果在恢复期内使用此酶的底物,也可以产生DDI。 

拓展指南:丙型肝炎相关指南:

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    2018-09-15 明月清辉

    谢谢分享,学习了

    0

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    2018-09-15 txqjm

    谢谢了,学习

    0

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    2018-09-15 liumin1987

    专家共识,学习了。

    0