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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1972 1
1976 1
1980 1
1983 1
1990 2
1991 1
1992 5
1994 1
1996 1
1997 1
1998 1
2001 4
2002 1
2004 4
2005 3
2006 1
2007 3
2008 5
2009 3
2010 3
2011 5
2012 3
2013 3
2014 1
2015 1
2016 3
2017 3
2018 6
2019 4
2020 2
2021 3
2022 3
2023 4
2024 0

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77 results

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Page 1
Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations.
Liu D, Meyer D, Fennessy B, Feng C, Cheng E, Johnson JS, Park YJ, Rieder MK, Ascolillo S, de Pins A, Dobbyn A, Lebovitch D, Moya E, Nguyen TH, Wilkins L, Hassan A; Psychiatric Genomics Consortium Phase 3 Targeted Sequencing of Schizophrenia Study Team; Burdick KE, Buxbaum JD, Domenici E, Frangou S, Hartmann AM, Laurent-Levinson C, Malhotra D, Pato CN, Pato MT, Ressler K, Roussos P, Rujescu D, Arango C, Bertolino A, Blasi G, Bocchio-Chiavetto L, Campion D, Carr V, Fullerton JM, Gennarelli M, González-Peñas J, Levinson DF, Mowry B, Nimgaokar VL, Pergola G, Rampino A, Cervilla JA, Rivera M, Schwab SG, Wildenauer DB, Daly M, Neale B, Singh T, O'Donovan MC, Owen MJ, Walters JT, Ayub M, Malhotra AK, Lencz T, Sullivan PF, Sklar P, Stahl EA, Huckins LM, Charney AW. Liu D, et al. Nat Genet. 2023 Mar;55(3):369-376. doi: 10.1038/s41588-023-01305-1. Epub 2023 Mar 13. Nat Genet. 2023. PMID: 36914870 Free PMC article.
Activity-by-contact model of enhancer-promoter regulation from thousands of CRISPR perturbations.
Fulco CP, Nasser J, Jones TR, Munson G, Bergman DT, Subramanian V, Grossman SR, Anyoha R, Doughty BR, Patwardhan TA, Nguyen TH, Kane M, Perez EM, Durand NC, Lareau CA, Stamenova EK, Aiden EL, Lander ES, Engreitz JM. Fulco CP, et al. Nat Genet. 2019 Dec;51(12):1664-1669. doi: 10.1038/s41588-019-0538-0. Epub 2019 Nov 29. Nat Genet. 2019. PMID: 31784727 Free PMC article.
We developed an experimental approach, CRISPRi-FlowFISH, to perturb enhancers in the genome, and we applied it to test >3,500 potential enhancer-gene connections for 30 genes. ...
We developed an experimental approach, CRISPRi-FlowFISH, to perturb enhancers in the genome, and we applied it to test >3,500 pote …
Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.
Wang A, Shen J, Rodriguez AA, Saunders EJ, Chen F, Janivara R, Darst BF, Sheng X, Xu Y, Chou AJ, Benlloch S, Dadaev T, Brook MN, Plym A, Sahimi A, Hoffman TJ, Takahashi A, Matsuda K, Momozawa Y, Fujita M, Laisk T, Figuerêdo J, Muir K, Ito S, Liu X; Biobank Japan Project; Uchio Y, Kubo M, Kamatani Y, Lophatananon A, Wan P, Andrews C, Lori A, Choudhury PP, Schleutker J, Tammela TLJ, Sipeky C, Auvinen A, Giles GG, Southey MC, MacInnis RJ, Cybulski C, Wokolorczyk D, Lubinski J, Rentsch CT, Cho K, Mcmahon BH, Neal DE, Donovan JL, Hamdy FC, Martin RM, Nordestgaard BG, Nielsen SF, Weischer M, Bojesen SE, Røder A, Stroomberg HV, Batra J, Chambers S, Horvath L, Clements JA, Tilly W, Risbridger GP, Gronberg H, Aly M, Szulkin R, Eklund M, Nordstrom T, Pashayan N, Dunning AM, Ghoussaini M, Travis RC, Key TJ, Riboli E, Park JY, Sellers TA, Lin HY, Albanes D, Weinstein S, Cook MB, Mucci LA, Giovannucci E, Lindstrom S, Kraft P, Hunter DJ, Penney KL, Turman C, Tangen CM, Goodman PJ, Thompson IM Jr, Hamilton RJ, Fleshner NE, Finelli A, Parent MÉ, Stanford JL, Ostrander EA, Koutros S, Beane Freeman LE, Stampfer M, Wolk A, Håkansson N, Andriole GL, Hoover RN, Machiela MJ, Sørensen KD, Borre M, Blot … See abstract for full author list ➔ Wang A, et al. Nat Genet. 2023 Dec;55(12):2065-2074. doi: 10.1038/s41588-023-01534-4. Epub 2023 Nov 9. Nat Genet. 2023. PMID: 37945903 Free PMC article.
Linkage disequilibrium between rare mutations.
Good BH. Good BH. Genetics. 2022 Apr 4;220(4):iyac004. doi: 10.1093/genetics/iyac004. Genetics. 2022. PMID: 35100407 Free PMC article.
Yet in contrast to single-site analogues like the site frequency spectrum, our theoretical understanding of linkage disequilibrium remains limited. ...
Yet in contrast to single-site analogues like the site frequency spectrum, our theoretical understanding of linkage disequilibrium re …
Polygenic adaptation: a unifying framework to understand positive selection.
Barghi N, Hermisson J, Schlötterer C. Barghi N, et al. Nat Rev Genet. 2020 Dec;21(12):769-781. doi: 10.1038/s41576-020-0250-z. Epub 2020 Jun 29. Nat Rev Genet. 2020. PMID: 32601318 Review.
Most adaption processes have a polygenic genetic basis, but even with the recent explosive growth of genomic data we are still lacking a unified framework describing the dynamics of selected alleles. Building on recent theoretical and empirical work we introduce the concep …
Most adaption processes have a polygenic genetic basis, but even with the recent explosive growth of genomic data we are still lacking a uni …
Controlling the Rate of GWAS False Discoveries.
Brzyski D, Peterson CB, Sobczyk P, Candès EJ, Bogdan M, Sabatti C. Brzyski D, et al. Genetics. 2017 Jan;205(1):61-75. doi: 10.1534/genetics.116.193987. Epub 2016 Oct 26. Genetics. 2017. PMID: 27784720 Free PMC article.
We show how FDR-controlling strategies can be adapted to account for this initial selection both with theoretical results and simulations that mimic the dependence structure to be expected in GWAS. ...
We show how FDR-controlling strategies can be adapted to account for this initial selection both with theoretical results and simulat …
Quantification of subclonal selection in cancer from bulk sequencing data.
Williams MJ, Werner B, Heide T, Curtis C, Barnes CP, Sottoriva A, Graham TA. Williams MJ, et al. Nat Genet. 2018 Jun;50(6):895-903. doi: 10.1038/s41588-018-0128-6. Epub 2018 May 28. Nat Genet. 2018. PMID: 29808029 Free PMC article.
Here we measure clone dynamics in human cancers by using computational modeling of subclonal selection and theoretical population genetics applied to high-throughput sequencing data. ...
Here we measure clone dynamics in human cancers by using computational modeling of subclonal selection and theoretical population gen …
77 results