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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


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Review
From molecules to medicine: thiol selective bioconjugation in synthesis of diagnostic and therapeutic radiopharmaceuticals
Iqra Bibi, Sajid Mushtaq, Kyo Chul Lee, Ji Ae Park, Jung Young Kim
Theranostics 2024; 14(6): 2396-2426. doi:10.7150/thno.95469
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Research Paper
Hepatic progenitor cell-originated ductular reaction facilitates liver fibrosis through activation of hedgehog signaling
Yonghong Hu, Xinyu Bao, Zheng Zhang, Long Chen, Yue Liang, Yan Qu, Qun Zhou, Xiaoxi Zhou, Jing Fang, Zhun Xiao, Yadong Fu, Hailin Yang, Wei Liu, Ying Lv, Hongyan Cao, Gaofeng Chen, Jian Ping, Hua Zhang, Yongping Mu, Chenghai Liu, Chao-Po Lin, Jian Wu, Ping Liu, Jiamei Chen
Theranostics 2024; 14(6): 2379-2395. doi:10.7150/thno.91572
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Review
Theranostics and artificial intelligence: new frontiers in personalized medicine
Gokce Belge Bilgin, Cem Bilgin, Brian J. Burkett, Jacob J. Orme, Daniel S. Childs, Matthew P. Thorpe, Thorvardur R Halfdanarson, Geoffrey B Johnson, Ayse Tuba Kendi, Oliver Sartor
Theranostics 2024; 14(6): 2367-2378. doi:10.7150/thno.94788
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Research Paper
HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy
Tuo Zhang, Yuntong Tong, Rengguang Zhu, Yaoyun Liang, Jixian Zhang, Chujiao Hu, Meina He, Zhu Hu, Zhiyi Shen, Jin Niu, Jingjing Zhang, Yuanyuan Yu, Bangming Jin, Shan Lei, Zhirui Zeng, Yingmin Wu, Zengmei Cheng, Ziwen Xiao, Bing Guo, Shuyun Zhao, Guoqiang Xu, Wei Pan, Tengxiang Chen
Theranostics 2024; 14(6): 2345-2366. doi:10.7150/thno.95164
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Review
Transglutaminase 2 in diabetes mellitus: Unraveling its multifaceted role and therapeutic implications for vascular complications
Kwon-Soo Ha
Theranostics 2024; 14(6): 2329-2344. doi:10.7150/thno.95742
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Review
Role of the gut microbiota in tumorigenesis and treatment
Qingya Liu, Yun Yang, Meng Pan, Fan Yang, Yan Yu, Zhiyong Qian
Theranostics 2024; 14(6): 2304-2328. doi:10.7150/thno.91700
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Research Paper
Programming peptide-oligonucleotide nano-assembly for engineering of neoantigen vaccine with potent immunogenicity
Zhichu Xiang, Jianhua Lu, Shangrui Rao, Chenxing Fu, Yuying Yao, Yongdong Yi, Yang Ming, Weijian Sun, Weisheng Guo, Xiaoyuan Chen
Theranostics 2024; 14(6): 2290-2303. doi:10.7150/thno.93395
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Review
Extracellular vesicles as carriers of mRNA: Opportunities and challenges in diagnosis and treatment
Robert D. Kirian, Darby Steinman, Christopher M. Jewell, Hannah C. Zierden
Theranostics 2024; 14(5): 2265-2289. doi:10.7150/thno.93115
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Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile



Special Issue: Osteoarthritis Theranostics. Guest Editors: Dr. WEN, CHUNYI, Dr. Magali Cucchiarini.


CFP: Special issue on mRNA-based vaccine and therapy. Guest Editors: Guocan Yu (Tsinghua University, China), Qiaobing Xu (Tufts University, USA), Wei Tao (Harvard Medical School, USA)


Radiolabeling of biomolecules and cells with radiolabeled prosthetic groups has significant implications for nuclear medicine, imaging, and radiotherapy. Achieving site-specific and controlled incorporation of radiolabeled prostheses under mild reaction conditions is crucial for minimizing the impact on the bioactivity of the radiolabeled compounds. The targeting of natural and abundant amino acids during radiolabeling of biomolecules often results in nonspecific and uncontrolled modifications. Cysteine is distinguished by its low natural abundance and unique nucleophilicity. It is therefore an....
Rationale: Primordial follicles are limited in number and cannot be regenerated, dormant primordial follicles cannot be reversed once they enter a growth state. Therefore, the length of the female reproductive lifespan depends on the orderly progression and selective activation of primordial follicles, the mechanism of which remains unclear. Methods: We used human ovarian cortical biopsy specimens, granulosa cells from diminished ovarian reserve (DOR) patients, Hdac6-overexpressing transgenic mouse model, and RNA sequencing to analyze the crucial roles of histone deacetylase 6 (HDAC6) in fertility....

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Review
Herbal Theranostics: Controlled, Targeted Delivery and Imaging of Herbal Molecules
Aseem Setia, Bhaskar Vallamkonda, Randheer Reddy Challa, Abhishesh Kumar Mehata, Paresh Badgujar, Madaswamy S. Muthu
Nanotheranostics 2024; 8(3): 344-379. doi:10.7150/ntno.94987
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