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Insights into the mechanisms of Th17 differentiation and the Yin-Yang of Th17 cells in human diseases

期刊: MOLECULAR IMMUNOLOGY, 2021; 134 ()

Th17 cells are a lineage of CD4(+)T helper cells with Th17-specific transcription factors ROR gamma t and RoR alpha. Since its discovery in 2005, rese......

Up-regulation of BTLA expression in myeloid dendritic cells associated with the treatment outcome of neonatal sepsis

期刊: MOLECULAR IMMUNOLOGY, 2021; 134 ()

Dentritic cells (DCs) dysfunction has been verified detrimental for sepsis and B and T lymphocyte attenuator (BTLA) is an immune-regulatory receptor s......

Inhibition of regulator of G protein signaling 10, aggravates rheumatoid arthritis progression by promoting NF-kappa B signaling pathway

期刊: MOLECULAR IMMUNOLOGY, 2021; 134 ()

Rheumatoid arthritis (RA) is the most common inflammatory arthropathy, with evidence pointing to an immune-mediated etiology that propagates chronic i......

Potential of Forsythoside I as a therapeutic approach for acute lung injury: Involvement of TXNIP/NLRP3 inflammasome

期刊: MOLECULAR IMMUNOLOGY, 2021; 134 ()

Objective: To explore the role of Forsythoside I (FI) in acute lung injury (ALI) mouse and its underling mechanism. Methods: The cell models of ALI ar......

Thymoquinone, extract from Nigella sativa seeds, protects human skin keratinocytes against UVA-irradiated oxidative stress, inflammation and mitochondrial dysfunction

期刊: MOLECULAR IMMUNOLOGY, 2021; 135 ()

Ultraviolet A (UVA) irradiation caused skin keratinocytes to accumulate reactive oxygen species (ROS) leading to the skin injury. Thymoquinone (TQ) wa......

MEKK3 activates IRF7 to trigger a potent type I interferon induction in response to TLR7/9 signaling

期刊: MOLECULAR IMMUNOLOGY, 2021; 134 ()

Interferon regulatory factor 7 (IRF7) is a crucial regulator of type I interferons (IFNs) against pathogen infections and plays a significant role in ......

Brevilin A inhibits NLRP3 inflammasome activation in vivo and in vitro by acting on the upstream of NLRP3-induced ASC oligomerization

期刊: MOLECULAR IMMUNOLOGY, 2021; 135 ()

Brevilin A (BA), is a natural biologically active ingredient derived from Centipeda minima with several reports of anti-cancer, while its anti-inflamm......

Extracellular histones aggravate inflammation in ARDS by promoting alveolar macrophage pyroptosis

期刊: MOLECULAR IMMUNOLOGY, 2021; 135 ()

Extracellular histones have been discovered to play a pathogenic role in ARDS, but the underlying mechanisms are yet to be fully defined. Alveolar mac......

PM2.5 and water-soluble components induce airway fibrosis through TGF-beta 1/Smad3 signaling pathway in asthmatic rats

期刊: MOLECULAR IMMUNOLOGY, 2021; 137 ()

Epidemiological studies have suggested that fine particulate matter (PM2.5) and asthma have been independently associated with pulmonary fibrosis but ......

Dermal macrophage and its potential in inducing hair follicle regeneration

期刊: MOLECULAR IMMUNOLOGY, 2021; 134 ()

Hair follicle (HF) is an excellent mini-model to study adult tissue regeneration, since it can regenerate itself under appropriate stress settings via......

Anti-type I allergic effects of Jing-Fang powder extracts via PI3K/Akt pathway in vitro and in vivo

期刊: MOLECULAR IMMUNOLOGY, 2021; 135 ()

Jing-Fang powder (Schizonepeta tenuifolia Briq. and Saposhnikovia divaricata (Turcz.) Schischk.) was used to treat chronic bronchitis, asthma and chro......

LINC00337 induces tumor development and chemoresistance to paclitaxel of breast cancer by recruiting M2 tumor-associated macrophages

期刊: MOLECULAR IMMUNOLOGY, 2021; 138 ()

Background: M2 tumor-associated macrophages are closely related to the progression and prognosis of breast cancer (BCa), and could be regulated by lon......

Genome-wide identification of NOD-like receptors and their expression profiling in mucosal tissues of turbot (Scophthalmus maximus L.) upon bacteria challenge

期刊: MOLECULAR IMMUNOLOGY, 2021; 134 ()

The innate immune system plays an important role in host defense against pathogenic infections. In the innate immune system, several families of innat......

Expression of leukocyte immunoglobulin-like receptor subfamily B expression on immune cells in hepatocellular carcinoma

期刊: MOLECULAR IMMUNOLOGY, 2021; 136 ()

Background: Leukocyte immunoglobulin-like receptor subfamily B (LILRB) is a group of inhibitory receptors involved in innate immune mainly expressed o......

Intra-arterial infusion chemotherapy utilizing cisplatin inhibits bladder cancer by decreasing the fibrocytic myeloid-derived suppressor cells in an m6A-dependent manner

期刊: MOLECULAR IMMUNOLOGY, 2021; 137 ()

Intra-arterial infusion chemotherapy (IAIC), using immunomodulatory cisplatin, is a novel treatment for bladder cancer (BC) that allows the delivery o......

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