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Rescue of maternal immune activation-induced behavioral abnormalities in adult mouse offspring by pathogen-activated maternal T-reg cells

期刊: NATURE NEUROSCIENCE, 2021; 24 (6)

Maternal immune activation (MIA) induced by lipopolysaccharides or polyinosinic:polycytidylic acid injections can induce behavioral abnormalities in a......

A neural circuit for excessive feeding driven by environmental context in mice

期刊: NATURE NEUROSCIENCE, 2021; 24 (8)

Despite notable genetic influences, obesity mainly results from the overconsumption of food, which arises from the interplay of physiological, cogniti......

CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation

期刊: NATURE NEUROSCIENCE, 2021; 24 (6)

The authors find that calcium signaling triggers liquid-liquid phase separation of CaMKII. This reorganizes the postsynaptic structure, acting as a po......

Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents

期刊: NATURE NEUROSCIENCE, 2021; 24 (4)

Oxytocin (OT) orchestrates social and emotional behaviors through modulation of neural circuits. In the central amygdala, the release of OT modulates ......

Collicular circuits for flexible sensorimotor routing

期刊: NATURE NEUROSCIENCE, 2021; 24 (8)

Duan et al. reveal circuit mechanisms of executive control in the midbrain superior colliculus (SC), where response inhibition and context-based vecto......

Wireless multilateral devices for optogenetic studies of individual and social behaviors

期刊: NATURE NEUROSCIENCE, 2021; 24 (7)

The authors introduce advanced technology for controlled wireless light delivery in optogenetics applications with real-time user programming capacity......

Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis

期刊: NATURE NEUROSCIENCE, 2021; 24 (7)

Single-cell transcriptomics provide a systematic map of gene expression in different human cell types. The next challenge is to systematically underst......

A genetically encoded sensor for measuring serotonin dynamics

期刊: NATURE NEUROSCIENCE, 2021; 24 (5)

Serotonin (5-HT) is a phylogenetically conserved monoamine neurotransmitter modulating important processes in the brain. To directly visualize the rel......

Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders

期刊: NATURE NEUROSCIENCE, 2021; 24 (9)

Yang et al. generated a genomic atlas of protein levels in brain, cerebrospinal fluid and plasma and used human genetics approaches to identify protei......

Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states

期刊: NATURE NEUROSCIENCE, ; ()

Pain hypersensitivity can result from tissue injury and from depression. This study in mice shows that distinct thalamocortical pathways mediate allod......

Gene-based therapies for neurodegenerative diseases

期刊: NATURE NEUROSCIENCE, 2021; 24 (3)

Gene therapy is making a comeback. With its twin promise of targeting disease etiology and 'long-term correction', gene-based therapies (defined here ......

Phase separation at the synapse

期刊: NATURE NEUROSCIENCE, 2020; 23 (3)

Phase separation is emerging as a versatile means for cellular sub-compartment formation. Chen et al. review recent advances of dense synaptic assembl......

Spatiotemporal single-cell analysis of gene expression in the mouse suprachiasmatic nucleus

期刊: NATURE NEUROSCIENCE, 2020; 23 (3)

Mammalian circadian behaviors are orchestrated by the suprachiasmatic nucleus (SCN) in the ventral hypothalamus, but the number of SCN cell types and ......

Within-group synchronization in the prefrontal cortex associates with intergroup conflict

期刊: NATURE NEUROSCIENCE, 2020; 23 (6)

Using fNIRS hyperscanning in three-versus-three-person intergroup competitions, this study shows that in-group bonding and within-group synchronizatio......

Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinction

期刊: NATURE NEUROSCIENCE, 2020; 23 (6)

Marshall et al. show that regions of the genome adopt a noncanonical Z-DNA state in the prefrontal cortex in response to fear learning and that bindin......

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