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A survey of optimal strategy for signature-based drug repositioning and an application to liver cancer

期刊: ELIFE, 2022; 11 ()

Pharmacologic perturbation projects, such as Connectivity Map (CMap) and Library of Integrated Network-based Cellular Signatures (LINCS), have produce......

JIF:7.448

A non-bactericidal cathelicidin provides prophylactic efficacy against bacterial infection by driving phagocyte influx

期刊: ELIFE, 2022; 11 ()

The roles of bactericidal cathelicidins against bacterial infection have been extensively studied. However, the antibacterial property and mechanism o......

JIF:7.448

Stability and asynchrony of local communities but less so diversity increase regional stability of Inner Mongolian grassland

期刊: ELIFE, 2022; 11 ()

Extending knowledge on ecosystem stability to larger spatial scales is urgently needed because present local-scale studies are generally ineffective i......

JIF:7.448

Cold protection allows local cryotherapy in a clinical-relevant model of traumatic optic neuropathy

期刊: ELIFE, 2022; 11 ()

Therapeutic hypothermia (TH) is potentially an important therapy for central nervous system (CNS) trauma. However, its clinical application remains co......

JIF:7.448

Palatal morphology predicts the paleobiology of early salamanders

期刊: ELIFE, 2022; 11 ()

Ecological preferences and life history strategies have enormous impacts on the evolution and phenotypic diversity of salamanders, but the yet establi......

JIF:7.448

trim-21 promotes proteasomal degradation of CED-1 for apoptotic cell clearance in C. elegans

期刊: ELIFE, 2022; 11 ()

The phagocytic receptor CED-1 mediates apoptotic cell recognition by phagocytic cells, enabling cell corpse clearance in Caenorhabditis elegans. Wheth......

JIF:7.448

Zika virus causes placental pyroptosis and associated adverse fetal outcomes by activating GSDME

期刊: ELIFE, 2022; 11 ()

Zika virus (ZIKV) can be transmitted from mother to fetus during pregnancy, causing adverse fetal outcomes. Several studies have indicated that ZIKV c......

JIF:7.448

Drosophila mechanical nociceptors preferentially sense localized poking

期刊: ELIFE, 2022; 11 ()

Mechanical nociception is an evolutionarily conserved sensory process required for the survival of living organisms. Previous studies have revealed mu......

JIF:7.448

From Gondwana to the Yellow Sea, evolutionary diversifications of true toads Bufo sp. in the Eastern Palearctic and a revisit of species boundaries for Asian lineages

期刊: ELIFE, 2022; 11 ()

Taxa with vast distribution ranges often display unresolved phylogeographic structures and unclear taxonomic boundaries resulting in hidden diversity.......

JIF:7.448

SEXUAL CONFLICT Evolving new ways to secure a mate

期刊: ELIFE, 2022; 11 ()

Fossils shed light on mating strategies in scorpionflies.

JIF:7.448

Mapping the single-cell landscape of acral melanoma and analysis of the molecular regulatory network of the tumor microenvironments

期刊: ELIFE, 2022; 11 ()

Acral melanoma (AM) exhibits a high incidence in Asian patients with melanoma, and it is not well treated with immunotherapy. However, little attentio......

JIF:7.448

Tadr is an axonal histidine transporter required for visual neurotransmission in Drosophila

期刊: ELIFE, 2022; 11 ()

Neurotransmitters are generated by de novo synthesis and are essential for sustained, high-frequency synaptic transmission. Histamine, a monoamine neu......

JIF:7.448

Air pollution particles hijack peroxidasin to disrupt immunosurveillance and promote lung cancer

期刊: ELIFE, 2022; 11 ()

Although fine particulate matter (FPM) in air pollutants and tobacco smoke is recognized as a strong carcinogen and global threat to public health, it......

JIF:7.448

Brucella activates the host RIDD pathway to subvert BLOS1-directed immune defense

期刊: ELIFE, 2022; 11 ()

The phagocytosis and destruction of pathogens in lysosomes constitute central elements of innate immune defense. Here, we show that Brucella, the caus......

JIF:7.448

Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation

期刊: ELIFE, 2022; 11 ()

Chronic autoimmune diseases are associated with mutations in PTPN22, a modifier of T cell receptor (TCR) signaling. As with all protein tyrosine phosp......

JIF:7.448

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